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| * https://herb.co/news/health/autoimmune-diseases/ | | * https://herb.co/news/health/autoimmune-diseases/ |
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| == Rheumatoid arthritis and Osteoarthritis ==
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| * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453762/ ''''''Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis'''''' at ncbi.nlm.nih.gov], a 2008 study published in [[w:Arthritis Research & Therapy]] - Results: ''CB1 and CB2 protein and RNA were present in the synovia of OA and RA patients. Cannabinoid receptor stimulation of fibroblast-like cells from OA and RA patients produced a time-dependent phosphorylation of extracellular signal-regulated kinase (ERK)-1 and ERK-2 which was significantly blocked by the CB1 antagonist SR141716A. The endocannabinoids anandamide (AEA) and 2-arachidonyl glycerol (2-AG) were identified in the synovial fluid of OA and RA patients. However, neither AEA nor 2-AG was detected in synovial fluid from normal volunteers. FAAH was active in the synovia of OA and RA patients and was sensitive to inhibition by URB597 (3'-(aminocarbonyl) [1,1'-biphenyl]-3-yl)-cyclohexylcarbamate).''
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