User:Jukeboksi/Wiki.study/Natural therapeutics

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Revision as of 15:21, 17 December 2021 by Jukeboksi (talk | contribs) (rm 'Holy Smoke: Frankincense and Cannabis as Medicinal Incense', an review article at EmeraldPharms.com. 404, no archive.org copy, cannot be found with a search engine)
w:Usnea is a w:genus of w:lichen. They are hybrid lifeforms: part w:fungus, part air w:algae. Usnea contains w:Doxycycline[citation needed], an w:antibiotic.

Nature provides us with many healing agents but these are often pushed to the periphery of public knowledge to ensure big pharma profits.

Disclaimer: User:Jukeboksi is not a doctor nor a scientist, but just a concerned citizen.

Why natural therapeutics: In the Spring of 2017 my late dad, Mauri Heikkurinen (RIP) fell ill with Acute myeloid leukemia (AML). I had heard on a cursory level that cannabinoids could help with cancer so I started doing a little research on how CBD oil could help my dad's condition. This natural therapeutics article grew out of that. Dad passed away in September 2017, but I am hopeful that the information in the article can help people find relief from natural therapeutics for their condition.

How is this organized?

The main content is organized alphabetically by illness and then in subheadings alphabetically by natural therapeutic with the linked studies and reporting in reverse chronological order.

Additionally subsections of #Garden are organized per natural therapeutic alphabetically and contains intra-article links to the illnesses where the natural therapeutic appears to have had an positive effect on.

Alzheimer's

Alzheimer's and cannabis

 
Modeled is the toxic β-amyloid transmembrane protein structure.
 
Cannabis sativa seedling in Poland could use a little water.

Cannabis has been found beneficial to w:Alzheimer's disease sufferers. This is strongly supported by in-vivo i.e. animal "model" studies, where they cause a similar disease in the test animals and then try different substances on them and see which ones are doing well and which ones are not.

It would seem that w:Tetrahydrocannabinol (THC) is better than any other chemical we know at inhibiting the formation of toxic beta amyloid protein plaque on braincells which causes the deteriation in Alzheimer's disease, but have a look yourself. (own assesment based on abstracts of in-vivo studies and reporting)

See #Cannabis therapeutics for list of other illnesses that cannabis looks to work against.


Scientific research about Alzheimer's and cannabis (in reverse chronology)

Links about Alzheimer's disease and cannabis

Alzheimer's and turmeric

 
Turmeric (Curcuma Longa) of genus Curcuma.


Links about Alzheimer's disease and turmeric

Alzheimer's and ginger

 
Ginger plant

Ginger may improve brain functioning and protect against Alzheimer's disease [1st seen in 4]


Antibiotics from nature

Antibiotic blackberries

 
Ripe, ripening and raw blackberries

Blackberries kill antibiotic resistant staphylococcus aureus bacteria[1]. Irish teen awarded prize for discovery.[2]

Antibiotic cannabis leaves

Cannabis leaves found effective against antibiotic resistant bacteria.[3]

Studies about antibiotic cannabis

Links about antibiotic cannabis

Antibiotic thyme

Thyme contains w:thymol, which is a natural antibiotic. Oil of thyme, the essential oil of common thyme (w:Thymus vulgaris), contains 20–54% thymol and other substances. (Wikipedia)


Autism

Autism and cannabis


Autoimmune diseases

Autoimmune diseases and cannabis

Cannabis helps with many autoimmune diseases due to its anti-inflammatory and other properties.

Links about autoimmune diseases and cannabis


Rheumatoid arthritis and cannabis

Cannabis helps with Rheumatoid arthritis.

Studies about rheumatic diseases and cannabis

Links about Rheumatoid arthritis and cannabis


Rheumatoid arthiritis and ginger

Gingerol seems to be effective in an animal model of rheumatoid arthritis.[4]

~ Wikipedia on Gingerol and rheumatoid arthritis as of 2019-11

Lupus and cannabis

Cannabis helps with Systemic lupus erythematosus


Coeliac disease and cannabis

Cannabis helps with Coeliac disease.

Psoriasis and cannabis

You could also be looking for dermatitis, also known as eczema.

Cannabis helps with Psoriasis and when applied externally.


Cancers

Cancers and turmeric

Curcumin has been found to have anti-cancer properties. Curcumin interferes with cancer via multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation[5].

Cancers and cannabis

Key things everyone needs to know about cancers and cannabis

Warning: Smoking the cannabis as the method of cannabinoid delivery the smoke contains quite a few carcinogenic substances i.e. cancer inducing substances. See the section administering cannabis for alternatives to smoking it.


Internet is rife with stories about winning the battle against cancer with the help of phytocannabinoids. What does the science say?

Cannabis is...

  1. Anti-proliferative - cannabis is against tumor growth [6]
  2. Anti-metastatic - cannabis is against cancer spreading to other parts in the body because of metastatic activity[6]
  3. Anti-angiogenetic - cannabis is against new blood vein growth to tumor[6]
  4. Apoptotic - cannabis causes cancer cells to programmedly kill themselves via Apoptosis. [6]
  5. Pain relief - cannabis works very well against the somatic and nonsomatic pains brought on by cancer.
  6. Appetite stimulator - cannabis helps maintain a good appetite.
  7. Anti-nauseatic - cannabis helps with the chemotherapy-induced nausea and vomiting if you receive chemotherapy. World's first study of cannabis for chemotherapy's negative effects is underway in Australia. [7] [8]

Phytocannabinoids are harmless to healthy cannabinoid receptor containing cells.


Scientific works about cannabis and cancers in general

Links about cannabis and cancer in general

Ongoing and upcoming cannabis and cancer

"Official" information

Cannabis and cancers advocacy

Testimonies about cannabis and cancer

Cancer surviving cases with cannabis

Learn from videos by experts in phytocannabinoid treatment of cancers

People:

Videos


See also: Cancers and turmeric (intra-article link)

Chemotherapy and cannabis


Adenocarcinoma

Adenocarcinoma is a type of cancerous tumor that can occur in several parts of the body. (Wikipedia)

Links


Brain cancer

A glioma is a type of tumor that starts in the glial cells of the brain or the spine. (Wikipedia)

w:Astrocytomas are a type of w:brain tumor. They originate in a particular kind of glial cells, star-shaped brain cells in the w:cerebrum called w:astrocytes. This type of tumor does not usually spread outside the brain and spinal cord and it does not usually affect other organs. Astrocytomas are the most common w:glioma and can occur in most parts of the brain and occasionally in the spinal cord. (Wikipedia on 2020-07-16)

A blastoma is a type of cancer, more common in children, that is caused by malignancies in precursor cells. (Wikipedia)

A Glioblastoma is the most aggressive form of brain cancer, but it may potentially be treated with cannabis.[9]


Brain cancer and cannabis

In 2018 Insys Therapeutics announced the the FDA has given CBD an orphan drug designation (ODD) to CBD for treating gliomas.[10]

Studies about brain tumors and cannabis

Links about brain cancer and cannabis


Breast cancer

Breast cancer and cannabis


Breast cancer and frankincense

 
A flowering Boswellia sacra tree

Boswellia is a genus of trees in the order Sapindales, known for their fragrant resin. The biblical incense w:frankincense was an extract from the resin of the tree Boswellia sacra, and is now produced also from B. frereana. (Wikipedia)

Scientific articles about frankincense healing

Breast cancer and ginger

“Gingerol has been investigated w:in vitro for its effect on cancerous tumors of the bowel,[11][12] breast tissue,[13] ovaries,[14] and pancreas,[15] with positive results.”

~ Wikipedia on Gingerol as of 2019-11

Cervical cancer

Cervical cancer and cannabis


Colon cancer

Colon cancer and cannabis


Colon cancer and ginger

“Gingerol has been investigated w:in vitro for its effect on cancerous tumors of the bowel,[11][12] breast tissue,[13] ovaries,[14] and pancreas,[15] with positive results.”

~ Wikipedia on Gingerol as of 2019-11

Colon cancer and dandelion root

The Dandelion Root Project at University of Windsor, Ontario has studied dandelion root since 2009 and they state on on their website:

“Since the commencement of this project, we have been able to successfully assess the effect of a simple water extract of dandelion root in various human cancer cell types, in the lab and we have observed its effectiveness against human T cell leukemia, chronic myelomonocytic leukemia, pancreatic and colon cancers, with no toxicity to non-cancer cells. Furthermore, these efficacy studies have been confirmed in animal models (mice) that have been transplanted with human colon cancer cells.[16]

~ The Dandelion Root Project on anti-cancer properties of dandelion root water extract

Langerhans cell sarcoma

Langerhans cell sarcoma and cannabis

Langerhans cell sarcoma is extremely rare.


Leukemia

There are 2 main types of Leukemia:

Leukemia and cannabis

Links about Lymphoid and Myeloid leukemia and cannabis

Leukemia and ginger

“Gingerol and its analogues have a favourable toxicity profile, but are cytotoxic towards a range of cancer cell lines including blood cancer and lung cancer.[17]

~ Wikipedia on Gingerol and blood cancer and lung cancer as of 2019-11

Lymphoid leukemia and cannabis

Links about Lymphoid leukemia and cannabis


T cell leukemia and dandelion root

The Dandelion Root Project at University of Windsor, Ontario has studied dandelion root since 2009 and they state on on their website:

“Since the commencement of this project, we have been able to successfully assess the effect of a simple water extract of dandelion root in various human cancer cell types, in the lab and we have observed its effectiveness against human T cell leukemia, chronic myelomonocytic leukemia, pancreatic and colon cancers, with no toxicity to non-cancer cells. Furthermore, these efficacy studies have been confirmed in animal models (mice) that have been transplanted with human colon cancer cells.[16]

~ The Dandelion Root Project on anti-cancer properties of dandelion root water extract

Myeloid leukemia and cannabis

Links about Myeloid leukemia and cannabis


Chronic myelomonocytic leukemia and dandelion root

The Dandelion Root Project at University of Windsor, Ontario has studied dandelion root since 2009 and they state on on their website:

“Since the commencement of this project, we have been able to successfully assess the effect of a simple water extract of dandelion root in various human cancer cell types, in the lab and we have observed its effectiveness against human T cell leukemia, chronic myelomonocytic leukemia, pancreatic and colon cancers, with no toxicity to non-cancer cells. Furthermore, these efficacy studies have been confirmed in animal models (mice) that have been transplanted with human colon cancer cells.[16]

~ The Dandelion Root Project on anti-cancer properties of dandelion root water extract

Liver cancer

Liver cancer and cannabis


Lung cancer

Lung cancer and cannabis

Laboratory and mice studies seem to indicate that THC can slow down the growth of lung cancer tumours from growing by binding to the same receptors as epidermal growth factor (EGF): the epidermal growth factor receptors (EGFR).

Links to studies about lung cancer and cannabis '

Compendiums of information on lung cancer and cannabis

Lung cancer and cannabis in the media

Lung cancer and ginger

“Gingerol and its analogues have a favourable toxicity profile, but are cytotoxic towards a range of cancer cell lines including blood cancer and lung cancer.[18]

~ Wikipedia on Gingerol and blood cancer and lung cancer as of 2019-11

Lymphoma

Hodgkin's lymphoma is a type of lymphoma in which cancer originates from a specific type of white blood cells called lymphocytes. (Wikipedia)

Lymphoma and cannabis

Used to exist There was an article at herb.co Hodgkin’s Lymphoma: Does Cannabis Help? herb.co at stored in archive.org in Feb 2019. Article existed from June 2017 to at least February 2019. Found non-existent in Dec 2021, no information on why it was removed from the herb.co website.


Oral cancer

Oral cancer and cannabis


Osteosarcoma

w:Osteosarcoma is a bone cancer.

Osteosarcoma and cannabis

Used to be

  • There used to be an article www.rxleaf.com/post/12004/colorado-teen-sent-home-to-die-from-bone-cancer-but-cannabis-got-him-back-to-school. Link was found 404 and search on website didn't find it elsewhere. The removal of this content may be due to the kid's mother later stressing that cannabis didn't heal his son.[contacted 1]

Ovarian cancer

Ovarian cancer and cannabis

Links to studies about ovarian cancer and cannabis

Links to information about ovarian cancer and cannabis

Ovarian cancer and frankincense

Links to articles about frankincense healing '

Ovarian cancer and ginger

“Gingerol has been investigated w:in vitro for its effect on cancerous tumors of the bowel,[11][12] breast tissue,[13] ovaries,[14] and pancreas,[15] with positive results.”

~ Wikipedia on Gingerol as of 2019-11

Pancreatic cancer

Pancreatic cancer and cannabis

Studies about pancreatic cancer and cannabis

Pancreatic cancer and ginger

 
The ginger plant has shown effects against cancers in vitro, so in vivo studies are needed.

“Gingerol has been investigated w:in vitro for its effect on cancerous tumors of the bowel,[11][12] breast tissue,[13] ovaries,[14] and pancreas,[15] with positive results.”

~ Wikipedia on Gingerol as of 2019-11

Pancreatic cancer and dandelion root

 
The dandelion root contains the keys against many cancers.

Hand coloured print, plate 1 of Dens Leonis in A Curious Herbal, 1737 by Elizabeth Blackwell

The Dandelion Root Project at University of Windsor, Ontario has studied dandelion root since 2009 and they state on on their website:

“Since the commencement of this project, we have been able to successfully assess the effect of a simple water extract of dandelion root in various human cancer cell types, in the lab and we have observed its effectiveness against human T cell leukemia, chronic myelomonocytic leukemia, pancreatic and colon cancers, with no toxicity to non-cancer cells. Furthermore, these efficacy studies have been confirmed in animal models (mice) that have been transplanted with human colon cancer cells.[16]

~ The Dandelion Root Project on anti-cancer properties of dandelion root water extract

Studies about pancreatic cancer and dandelion root



Prostate cancer

Prostate cancer and cannabis

Cannabis helps with prostate cancer.

Prostate cancer and dandelion root


Skin cancer

Skin cancer and cannabis

Melanoma

Melanoma and cannabis

Melanoma and dandelion root


Testicular cancer

Testicular cancer and cannabis


Thyroid cancer

Thyroid cancer and cannabis


Crohn's disease

Crohn's disease and cannabis

Study shows THC helps with Crohn's disease.


Epilepsy

Epilepsy and cannabis

 
Full extract cannabis oil in a syringe for easy dosing and travel is usually administered in drops to the gums or under the tongue.

Cannabis can be used to treat epilepsy.

Studies about epilepsies and cannabis

Links about epilepsies and cannabis

Dravet syndrome

Dravet syndrome and cannabis

w:Dravet syndrome, previously known as severe myoclonic epilepsy of infancy (SMEI), is a type of w:epilepsy with seizures that are often triggered by hot temperatures or w:fever.

In a 2018 trial 'A prospective open‐label trial of a CBD/THC cannabis oil in dravet syndrome' the reasearchers found that when treating Dravet syndrome with 50:1 CBD:THC-ratio oil "There was a statistically significant improvement in quality of life, reduction in EEG spike activity, and median motor seizure reduction of 70.6%, with 50% responder rate of 63%.". CTVNews.ca article 'Cannabis oil with THC may help treat kids with severe epilepsy' reporting on the study


Dermatological conditions

Dermatological conditions and cannabis

#Psoriasis and cannabis is listed under autoimmune diseases.

Dermatitis

Dermatitis, also known as eczema, is a group of diseases that results in inflammation of the skin that includes atopic dermatitis, allergic contact dermatitis, irritant contact dermatitis and stasis dermatitis. (Adapted from Wikipedia)


Lyme disease

Lyme disease and stevia

Lyme disease also known as Lyme borreliosis, is an infectious disease caused by a bacterium named Borrelia spread by ticks.

Stevia is a sweetener and sugar substitute extracted from the leaves of the plant species Stevia rebaudiana, native to Brazil and Paraguay.

In vitro studied have foundStevia works against the Lyme disease.[19]

Studies on stevia and Lyme disease

Links about stevia and Lyme disease


Migraines

Migraines and cannabis

It has been suggested that clinical endocannabinoid deficiency syndrome (CEDS) may be causing migraines. Many studies found medical cannabis as an effective prophylaxis against migraine attacks, especially the high CBD strains.

Scientific articles about migraines and cannabis

Compediums about migraines and cannabis

Links to articles about migraines and cannabis

Pain

Pain and cannabis

“You just don't feel like thinking about the pain.”

~ Apotheker Jukeboksi on somatic pain relief with cannabis

“There is more to it than that.”

~ Science on above quote

Cannabis is anti-inflammatory which helps relieve some of the pain. Pain is a signal of inflammation so counter-acting inflammation causing things cannabis naturally helps lower the pain.

Scientific articles about cannabis as an anti-pain agent

Links about cannabis as an anti-pain agent

Collections of information on pain management with cannabis


Parkinson's disease

Parkinson's disease and cannabis

Scientific studies on the issue of Parkinsons and cannabinoids

Compendiums of research

Articles in media


Non-somatic issues

Non-somatic issues with cannabis

Cannabis can help with various non-somatic problems such as psychiatry, depression and PTSD.

Depression

Depression and cannabis

Psychosis

Psychosis and cannabis

Studies about psychosis and cannabis

Articles about psychosis and cannabis

PTSD

PTSD and cannabis

Studies about medical cannabis for PTSD

Scientific studies about cannabis and PTSD

Links about medical cannabis for PTSD


Respiratory diseases

w:Respiratory diseases

For cancers of the lung and cannabis, see #Lung cancer, because it listed under #Cancers.

Asthma and cannabis

Common cough

Common cough and pineapple

 
Pineapple is effective cough medicine due to its Bromelain content.

Pineapple fruit and it's stem contain Bromelain, an enzyme with anti-cough properties.

In vitro and in vivo studies demonstrate that bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities.[20] Bromelain accounts for many therapeutic benefits like the treatment of angina pectoris, bronchitis, sinusitis, surgical trauma, and thrombophlebitis, debridement of wounds, and enhanced absorption of drugs, particularly antibiotics.[20]

Common cough and elderberries

 
Elderberries

Elderberries (or Elder) belong to the genus w:Sambucus and may be useful for various kinds of flu.

COVID-19 and cannabis

 
Existing knowledge of cannabis being a w:bronchodilator, existing research on #SARS and cannabis and fresh research on w:COVID-19 and w:cannabis strongly point to that cannabis is beneficial to those suffering of COVID-19. Cannabis is probably also recommendable for people getting vaccinated with a w:COVID-19 vaccine, due to its w:cytokine storm dampening and anti-inflammatory properties and other effects.

w:COVID-19 is a respiratory illness caused by w:Severe acute respiratory syndrome coronavirus 2.

Scientific papers

Reporting

SARS and cannabis

Scientific papers



Sclerosis

“In medicine, sclerosis is the stiffening of a structure, usually caused by a replacement of the normal organ-specific tissue with connective tissue.”

~ Wikipedia on Sclerosis

Amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis and cannabis

Cannabis helps with Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig's disease and motor neurone disease (MND).

Multiple sclerosis

Multiple sclerosis (MS) and cannabis

Cannabis is very good against Multiple sclerosis. Prince Charles knew of this way back in 1998[21].

Scientific articles about MS and cannabis

Compendiums of knowledge about MS and cannabis

Links about MS and cannabis


Seizures

Seizures and cannabis


Strokes

Strokes and cannabis


Traumatic brain injury

Traumatic brain injury and cannabis

Cannabis can help in healing from TBI


Garden

Blackberries

 
Ripe, ripening and raw blackberries

Blackberries kill antibiotic resistant staphylococcus aureus bacteria[1]. Irish teen awarded prize for discovery.[2]

Uses

  1. Antibiotic

Boswellia genus - Frankincense

 
A flowering Boswellia sacra tree

Boswellia is a genus of trees in the order Sapindales, known for their fragrant resin. The biblical incense w:frankincense was an extract from the resin of the tree Boswellia sacra, and is now produced also from B. frereana. (Wikipedia)

In vitro studies have found boswellia sacra essential oil to induce w:apoptosis and to suppress tumor agressiveness in #Breast cancer[22]

Medical professional testifies to frankincense oil killing cancer

Links to articles about frankincense healing '


Cannabis

 
Cannabis sativa seedling in Poland could use a little water.
 
Rare 11-leafer Cannabis sativa

Cannabis is the oldest and most versatile medicine known to humankind.

Cannabis sativa and Cannabis indica are the main cannabis variants though most strains are mixes of these. A third cannabis line is the Cannabis ruderalis, a rugged northern cannabis that has adapted to flower even under northern long summer days.

Cannabis therapeutics

 
Male Cannabis sativa plants in late flowering stages.

Cannabis can be applied to treat a wide assortment of illnesses. In this case it is called medical cannabis.

Some sources report cannabis useful against

  1. #Alzheimer's and cannabis - very strong evidence from in vivo studies
  2. #Autoimmune diseases and cannabis
    1. #Rheumatoid arthritis and cannabis
    2. #Lupus and cannabis
    3. #Coeliac disease and cannabis
    4. #Psoriasis and cannabis
  3. #Antibiotic cannabis leaves
  4. #Asthma and cannabis - bronchodialator
  5. #Autism and cannabis - many miracle stories
  6. #Cancers and cannabis - strong evidence of anti-cancer properties
    1. #Brain cancer and cannabis
    2. #Breast cancer and cannabis
    3. #Cervical cancer and cannabis
    4. #Colon cancer and cannabis
    5. #Langerhans cell sarcoma and cannabis
    6. #Leukemia and cannabis
    7. #Lymphoid leukemia and cannabis
    8. #Myeloid leukemia and cannabis
    9. #Liver cancer and cannabis
    10. #Lung cancer and cannabis
    11. #Lymphoma and cannabis
    12. #Oral cancer and cannabis
    13. #Ovarian cancer and cannabis
    14. #Pancreatic cancer and cannabis
    15. #Prostate cancer and cannabis
    16. #Skin cancer and cannabis
    17. #Melanoma and cannabis
    18. #Testicular cancer and cannabis
    19. #Thyroid cancer and cannabis
  7. #Crohn's disease and cannabis
  8. #Epilepsy and cannabis - very promising results
  9. #Dravet syndrome and cannabis
  10. #Dermatological conditions and cannabis
  11. #Migraines and cannabis
  12. #Pain and cannabis
  13. #Parkinson's disease and cannabis
  14. #Non-somatic issues with cannabis
    1. #Depression and cannabis
    2. #Psychosis and cannabis
    3. #PTSD and cannabis
  15. Scleroses
    1. #Amyotrophic lateral sclerosis and cannabis
    2. #Multiple sclerosis (MS) and cannabis
  16. #Respiratory diseases
    1. #COVID-19 and cannabis
    2. #SARS and cannabis
  17. #Seizures and cannabis
  18. #Strokes and cannabis
  19. #Traumatic brain injury and cannabis

Due to the inbuilt default to always take the safe route and also to backup the back of your fellow MD colleague the Wikipedia does not yield the right infos on how useful and versatile a medication cannabis is.

Research has been held back by arcane laws even as cannabis is the oldest medicine known to man and it should be gladly appreciated and not outlawed because of big pharma interests.

Medical cannabis research and information organizations

External links about cannabis as medicine

Literature about cannabis as a medicine


Anecdotal testimonies about medical cannabis

The endocannabinoid system

Main article in wikipedia Endocannabinoid system

Endocannabinoids are synthesized by our own bodies from Arachidonic acid, an essential polyunsaturated Omega-6 fatty acid[23].

Scientific articles about the endocannabinoid system

Articles about the endocannabinoid system

The endocannabinoid receptors

File:Stock-vector-human-endocannabinoid-system-target-active-in-male-and-female-body-1237262152.jpg
Prevalence of endocannabinoid receptors in the human body. Photo credit: ThanasStudio

Human body contains 2 types of endocannabinoid receptors CB1 and CB2, but cannabinoids have interactions also on some other receptors.

CB1 receptors

CB1 receptors predominantly located in the nervous system, connective tissues, gonads, glands, and organs[24].

CB2 receptors

CB2 receptors, primarily found in the immune system and also present in the spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands, and reproductive organs[24].

Endocannabinoids

 
Anandamide, an endogenous ligand of CB1 and CB2

The two main endocannabinoids are Anandamide and 2-AG.

Anandamide

Anandamide was discovered in 1992 and it binds to both CB1 and CB2 receptors. The name comes from the Sanskrit word 'Ananda' meaning 'bliss' and amide from its chemistry.

It has been referred to as the endocannabinoid version of THC.

Synthesis of Anandamide: Arachidonic acid -> Phosphatidylethanolamide + N-Acyltransferase -> N-arachidonoyl phosphatidylethanolamine + Phospholipase D -> Anandamide[25]

2-AG
 
2-Arachidonoylglycerol (2-AG) is an endogenous agonist of the CB1 receptor.

2-Arachidonoylglycerol aka. 2-AG was discovered in 1994-1995.

Synthesis of 2-AG: Arachidonic acid -> Phosphatidylinositol + Phospholipase Cs -> w:Diacylglycerol + Diacylglycerol lipase -> 2-AG[25]

N-Arachidonoyl dopamine

N-Arachidonoyl dopamine discovered in 2000.

2-Arachidonyl glyceryl ether

2-Arachidonyl glyceryl ether discovered in 2001.

Virodhamine

Virodhamine discovered in 2002

Lysophosphatidylinositol

Lysophosphatidylinositol is a contender to be the 6th endocannabinoid.



Phytocannabinoids

 
Female Cannabis indica plants. These are often good for pain relief producing a nice body stone.

Many people may know the 2 most prevalent phytocannabinoids, THC and CBD.

Studies about phytocannabinoids

Links about phytocannabinoids

List of known phytocannabinoids from Wikipedia:

THC

 
Tetrahydrocannabinol is a partial agonist of CB1 located mainly in the central nervous system, and the CB2 receptor mainly expressed in cells of the immune system.

Tetrahydrocannabinol was found in 1964[27] and it is the main psychoactive compound that brings the 'high' most recreational users are chasing.

THCA

Tetrahydrocannabinolic acid THCA is the what cannabis plants produce to fend off insects from harming it. In pure form THCA is a clear translucent crystalline of white color.

THC is produced from the raw THCA by a process called decarboxylation. Basically means to heat the stuff over certain temperature.

THCA found in raw marijuana apparently has some health enhancing properties. The issue is being researched.

CBD

 
Cannabidiol has very low affinity for the cannabinoid CB1 and CB2 receptors receptors but acts as an indirect antagonist of cannabinoid agonists.

Cannabidiol was isolated and identified from Cannabis sativa in 1940[27]. CBD is not psychoactive and it has the most medical applications of all phytocannabinoids.

“Cannabidiol has little affinity for CB1 and CB2 receptors but acts as an indirect antagonist of cannabinoid agonists.[28]

CBDA

Cannabidiolic Acid is the raw form. Decarboxylating CBDA yields CBD.

CBN

Cannabinol is a sleeping aid and has also other therapeutic qualities.

CBG

Cannabigerol

“Cannabigerol has been shown to promote apoptosis in cancer cells and inhibit tumor growth in mice. It acts as an α2-adrenergic receptor agonist, 5-HT1A receptor antagonist, and CB1 receptor antagonist.[29] It also binds to the CB2 receptor.[29]

Links about CBG

CBC

Cannabichromene

CBL

Cannabicyclol

CBV

Cannabivarin

THCV

Tetrahydrocannabivarin can be used to inhibit appetite.

Links about THCV

CBDV

Cannabidivarin

CBCV

Cannabichromevarin

CBGV

Cannabigerovarin

CBGM

Cannabigerol Monomethyl Ether

CBE

Cannabielsoin

CBT

Cannabicitran


Making cannabinoids with yeasts

Scientists have figured out how to splice the DNA of yeasts, so that they produce cannabinoids.[30]


Cannflavins

Cannaflavins A and B are very potent anti-inflammatory agents and thus help lessen the pain sensation originating from inflammation.

Scientific articles about cannflavins

Links about cannflavins


Terpenes in cannabis

Terpenes are a large and diverse class of organic compounds, produced by a variety of plants, particularly conifers, and by some w:insects.[31]

Links about terpenes found in cannabis


Synthetic cannabinoids

Synthetic cannabinoids are a class of molecules that bind to cannabinoid receptors in the body — the same receptors to which THC and CBD attach – which are cannabinoids in cannabis plants. (Wikipedia)

Word of caution: Many synthetic cannabinoids are dangerous and should not be administered by others than medical professionals.

Links about synthetic cannabinoids

Arachidonyl-2'-chloroethylamide (ACEA) is a synthetic agonist of the CB1 receptor. (Wikipedia)

Other plants that contain compounds that are active in cannabinoid receptors

  1. Echinacea contains N-alkylamides, that function via cannabimemetics to provide immune-boosting and is also used to relieve anxiety, fatigue, migraines and arthritis.[32]
  2. Black pepper contains high levels of the terpene called β-caryophyllene (BCP). BCP functions as a cannabinoid, and has a binding affinity with the CB2 receptor.[32]
  3. Flax (linen) seeds produce cannabinoid-like compounds very similar to CBD.[32]
  4. Cacao contains lots of magnesium, but also "happy-brain" chemicals like theobromine, phenethylamine, tryptophan, and anandamide. Cacao affects the endocannabinoid system by deactivating the enzyme called FAAH. This enzyme breaks down the endocannabinoid known as anandamide.[32]
  5. Black truffles contain anandamide.[32]
  6. Helichrysum umbraculigerum contains cannabigerol (CBG).[32]
  7. Rhododendron anthopogonoides (Chinese Labrador) contains anthopogocyclolic acid and anthopogochromenic acid and five related compounds known as synthetic analogues of cannabinoids: cannabichromene (CBC) type, cannabicyclol (CBL) type and cannabicitran (CBT) type, have been isolated together with geranyl orsellinic acid. [32]
  8. Liverwort contains Perrottetinene, a cannabinoid similar to THC.[33][32]

Administering cannabis

There are various other ways to administer cannabis methods besides smoking it:

Vaping cannabis

 
Cannabis concentrate known as "shatter"
  • Vaping (short for vaporizing), a method where the plant material is heated hot enough for the cannabinoids to become gaseous but cold enough that the plant matter does not combust and thus avoiding the carcinogens that come from burning the plant matter. Vaping is also the preferred method to consume concentrates.

Links


Oral cannabis

  • Edibles, tinctures and cannabis oil may be administered orally. Cannabinoids are soluble to alcohol and to fat and cannabis can be infused into many forms of edibles, but the problem is with efficiency as your stomach acids will destroy a lot of the cannabinoids.

Links


Rectal cannabis

  • Rectal - some doctors recommend taking cannabis rectally as this is method of administering allows you to take very large doses efficiently.[34]

Links


Topical cannabis

  • Topicals - for some skin affecting conditions this is a good way to administer the medicine. Many skin condition sufferers praise the combination of cannabis and coconut oil to make a topical to apply to the affected skin.

Naval cannabis

Right under the belly button there is a gland called Pechoti, which some say is a very good way to administer medical cannabis. Naval administration of medicine is a method used by the ancient Ayurvedic medicine.

Links


Celery


Dandelion

 
A dandelion flower

Dandelion root concentrates found effective against several cancers.

The Dandelion Root Project at University of Windsor, Ontario has studied dandelion root since 2009 and they state on on their website:

“Since the commencement of this project, we have been able to successfully assess the effect of a simple water extract of dandelion root in various human cancer cell types, in the lab and we have observed its effectiveness against human T cell leukemia, chronic myelomonocytic leukemia, pancreatic and colon cancers, with no toxicity to non-cancer cells. Furthermore, these efficacy studies have been confirmed in animal models (mice) that have been transplanted with human colon cancer cells.[16]

~ The Dandelion Root Project on anti-cancer properties of dandelion root water extract

Scientific studies about dandelion root and cancers

Summary of known dandelion health benefits

Links about dandelion and cancers


Elderberries

 
Elderberries

Elderberries (or Elder) belong to the genus w:Sambucus and may be useful for various kinds of flu.

Uses

  1. #Common cough and elderberries

Ginger

 
Ginger plant

Ginger (Zingiber officinale) is a flowering plant whose rhizome, ginger root or ginger, is widely used as a spice and a folk medicine.[36]

Ginger is in the family Zingiberaceae, which also includes turmeric (Curcuma longa), cardamom (Elettaria cardamomum), and galangal.[36]


“Gingerol has been investigated w:in vitro for its effect on cancerous tumors of the bowel,[11][12] breast tissue,[13] ovaries,[14] and pancreas,[15] with positive results.”

~ Wikipedia on Gingerol as of 2019-11

Scientific articles about ginger and health

Possible medical applications of ginger

  1. #Alzheimer's and ginger
  2. #Rheumatoid arthiritis and ginger
  3. #Breast cancer and ginger
  4. #Colon cancer and ginger
  5. #Leukemia and ginger
  6. #Lung cancer and ginger
  7. #Ovarian cancer and ginger
  8. #Pancreatic cancer and ginger


Chemistry of ginger

The characteristic fragrance and flavor of ginger result from volatile oils that compose 1-3% of the weight of fresh ginger, primarily consisting of zingerone, ls, and gingerols with [6]-gingerol (1-[4'-hydroxy-3'-methoxyphenyl]-5-hydroxy-3-decanone) as the major pungent compound.[37] Zingerone is produced from gingerols during drying, having lower pungency and a spicy-sweet aroma.[37] Shagoals are more pungent and have higher antioxidant activity but not found in raw ginger, but is formed from gingerols during heating, storage or via acidity.[37][38]

Fresh ginger also contains an enzyme zingibain which is a cysteine protease and has similar properties to rennet.[38]

 
Ginger rhizome (root)

11 health benefits of ginger at healthline.com (with sources)

  1. Ginger contains w:Gingerol, a substance with powerful anti-inflammatory and antioxidant properties.[1st seen in 4]
  2. Ginger can treat many forms of nausea, especially morning sickness and chemo-induced nausea[1st seen in 4]
  3. Ginger may reduce muscle pain and soreness [1st seen in 4]
  4. Ginger can help with w:osteoarthritis [1st seen in 4]
  5. Ginger may lower blood sugars [1st seen in 4]
  6. Ginger can help treat chronic indigestion [1st seen in 4]
  7. Ginger powder may significantly reduce menstrual pain [1st seen in 4]
  8. Ginger may lower cholesterol levels [1st seen in 4]
  9. Ginger contains gingerol, which may help to prevent cancers [1st seen in 4]
  10. Ginger may improve brain functioning and protect against Alzheimer's disease [1st seen in 4]
  11. Gingerol can help lower risk of infections [1st seen in 4]

Pineapple

 
Pineapple is effective cough medicine due to its Bromelain content.

Pineapple fruit and it's stem contain Bromelain, an enzyme with anti-cough properties.

In vitro and in vivo studies demonstrate that bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities.[20] Bromelain accounts for many therapeutic benefits like the treatment of angina pectoris, bronchitis, sinusitis, surgical trauma, and thrombophlebitis, debridement of wounds, and enhanced absorption of drugs, particularly antibiotics.[20]

Uses

  1. #Common cough and pineapple

Polyphenols

Polyphenols also known as polyhydroxyphenols) are a structural class of mainly natural, but also synthetic or semisynthetic, organic chemicals.”

More than 8,000 types of polyphenols have been identified. They can be further categorized into 4 main groups[39]

  1. Flavonoids (or bioflavonoids) (from the Latin word flavus, meaning yellow, their color in nature) are a class of plant and fungus secondary metabolites. (Wikipedia). These account for around 60% of all polyphenols. Examples include quercetin, kaempferol, catechins, and anthocyanins, which are found in foods like apples, onions, dark chocolate, and red cabbage.[39]
  2. Phenolic acids or phenolcarboxylic acids are types of aromatic acid compound (Wikipedia). This group accounts for around 30% of all polyphenols. Examples include stilbenes and lignans, which are mostly found in fruits, vegetables, whole grains, and seeds.[39]
  3. Polyphenolic amides. This category includes capsaicinoids in chili peppers and avenanthramides in oats.[39]
  4. Other polyphenols. This group includes resveratrol in red wine, ellagic acid in berries, curcumin in turmeric, and lignans in flax seeds, sesame seeds, and whole grains.[39]


Scientific articles

In Wikipedia

Links


Spirulina

 
Spirulina powder at 400X, wet mount.

Spirulina is a biomass of a (blue-green algae) that can be consumed by humans and other animals. The two species are Arthrospira platensis and A. maxima. ( Wikipedia )

Spirulina is extremely high in protein, contains an almost perfect balance of Omega-3 to Omega-6, and is rich in the following minerals: iron, copper, calcium, magnesium, potassium, phosphorous, selenium and zinc. It also contains high levels of vitamin A, C, E, K, B6, folate, niacin, pantothenic acid, riboflavin and thiamin. [40]

Spirulina has been found to help against [40]


Stevia

Stevia is a sweetener and sugar substitute extracted from the leaves of the plant species Stevia rebaudiana, native to Brazil and Paraguay.

Medical uses of stevia

  1. Stevia kills lyme disease



Tea


Turmeric

 
Turmeric (Curcuma Longa) of genus Curcuma.
 
Turmeric, used as spice, medicine and dye is made of ground roots of Curcuma Longa.

Turmeric contains curcumin, a curcuminoid.

Studies regarding turmeric

Possible medical applications of turmeric

  1. #Alzheimer's and turmeric
  2. #Cancers and turmeric


See also: Cancers and cannabis (intra-article link)


Information sources on natural therapeutics

Scientific

Other

In Wikimedia Foundation wikis

Sources of links

TrueActivist.com 100 studies on cannabis against cancers 2017

Source TrueActivist.com 2017 popular article 'There Are Now 100 Scientific Studies Proving Cannabis Cures Cancer', licensed under CC-BY 4.0, found via Suomen Kannabisyhdistys original post by Eva Surnameredacted (you know who you are) in Suomen kannabisfoorumi facebook page on 2019-11-10. Please keep the <ref group="1st seen in" name="trueactivist.com 2017"> attached to the entries.[1st seen in 5].

Jennifer Huse's list of 1008 studies

This is probably the same Jennifer Huse 'How I Kicked Cancer with Cannabis – Article by Jennifer A. Huse' at transhumanist-party.org that compiled the 1008 studies.

Safe to say that credit for compiling these goes to Jennifer A. Huse, you know who you are. Please send a current URL

[1st seen in 11]

[1st seen in 2]

References

  1. 1.0 1.1 https://www.ncbi.nlm.nih.gov/pubmed/28270804
  2. 2.0 2.1 https://www.hygiene-in-practice.com/publication/student-discovers-blackberry-antibiotic-for-multi-resistant-pathogens/
  3. https://www.researchgate.net/publication/322697165_In_vitro_antibacterial_activity_of_Cannabis_sativa_leaf_extracts_to_some_selective_pathogenic_bacterial_strains
  4. Funk, Janet L.; Frye, Jennifer B.; Oyarzo, Janice N.; Timmermann, Barbara N. (2009). "Comparative Effects of Two Gingerol-Containing Zingiber officinale Extracts on Experimental Rheumatoid Arthritis". Journal of Natural Products. 72 (3): 403–7. doi:10.1021/np8006183. PMC 2837120. PMID 19216559.
  5. https://www.sciencedirect.com/science/article/pii/S0304383508002310
  6. 6.0 6.1 6.2 6.3 https://herb.co/news/health/cannabis-kills-cancer/
  7. https://herb.co/news/health/world-first-cannabis-chemotherapy/
  8. https://www.medicinalcannabis.nsw.gov.au/clinical-trials/chemotherapy-trial
  9. https://www.medicaldaily.com/marijuana-just-might-help-cure-one-deadliest-forms-brain-cancer-410947
  10. http://wphealth.cc/2018/10/11/fda-approves-cannabis-for-brain-cancer-treatment/
  11. 11.0 11.1 11.2 11.3 11.4 "Ginger 'could halt bowel cancer'". w:BBC News. October 29, 2003.
  12. 12.0 12.1 12.2 12.3 12.4 Jeong, C.-H.; Bode, A. M.; Pugliese, A.; Cho, Y.-Y.; Kim, H.-G.; Shim, J.-H.; Jeon, Y.-J.; Li, H.; et al. (2009). "[6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A4 Hydrolase". Cancer Research. 69 (13): 5584–91. doi:10.1158/0008-5472.CAN-09-0491. PMID 19531649.
  13. 13.0 13.1 13.2 13.3 13.4 Lee, H; Seo, E; Kang, N; Kim, W (2008). "[6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells". The Journal of Nutritional Biochemistry. 19 (5): 313–9. doi:10.1016/j.jnutbio.2007.05.008. PMID 17683926.
  14. 14.0 14.1 14.2 14.3 14.4 Rhode, Jennifer; Fogoros, Sarah; Zick, Suzanna; Wahl, Heather; Griffith, Kent A; Huang, Jennifer; Liu, J Rebecca (2007). "Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells". BMC Complementary and Alternative Medicine. 7: 44. doi:10.1186/1472-6882-7-44. PMC 2241638. PMID 18096028.
  15. 15.0 15.1 15.2 15.3 15.4 Park, Yon Jung; Wen, Jing; Bang, Seungmin; Park, Seung Woo; Song, Si Young (2006). "[6]-Gingerol Induces Cell Cycle Arrest and Cell Death of Mutant p53-expressing Pancreatic Cancer Cells". Yonsei Medical Journal. 47 (5): 688–97. doi:10.3349/ymj.2006.47.5.688. PMC 2687755. PMID 17066513.
  16. 16.0 16.1 16.2 16.3 16.4 https://www.uwindsor.ca/dandelionrootproject/
  17. Semwal, RB; Semwal, DK; Combrinck, S; Viljoen, AM. "Gingerols and shogaols: Important nutraceutical principles from ginger". Phytochemistry. 117: 554–68. doi:10.1016/j.phytochem.2015.07.012. PMID 26228533.
  18. Semwal, RB; Semwal, DK; Combrinck, S; Viljoen, AM. "Gingerols and shogaols: Important nutraceutical principles from ginger". Phytochemistry. 117: 554–68. doi:10.1016/j.phytochem.2015.07.012. PMID 26228533.
  19. Effectiveness of Stevia Rebaudiana Whole Leaf Extract Against the Various Morphological Forms of Borrelia Burgdorferi in Vitro at pubmed.ncbi.nlm.nih.gov, a November 2015 in-vitro study published in European Journal of Microbiology and Immunology.
  20. 20.0 20.1 20.2 20.3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529416/
  21. https://www.theguardian.com/uk/1998/dec/24/monarchy.ameliagentleman
  22. https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-11-129 'Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells'], a 2011 in vitro study
  23. https://wakeup-world.com/2014/09/08/the-endocannabinoid-system-and-how-thc-cures-cancer/
  24. 24.0 24.1 https://patients4medicalmarijuana.wordpress.com/2017/07/06/how-and-why-your-brain-makes-its-own-cannabinoids/
  25. 25.0 25.1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685274/
  26. https://link.springer.com/chapter/10.1007/978-1-59259-947-9_2
  27. 27.0 27.1 https://en.wikipedia.org/wiki/Tetrahydrocannabinol
  28. Mechoulam, Raphael; Peters, Maximilian; Murillo-Rodriguez, Eric; Hanuš, Lumír O. (2007). "Cannabidiol – Recent Advances". Chemistry & Biodiversity. 4 (8): 1678–92. doi:10.1002/cbdv.200790147. PMID 17712814.
  29. 29.0 29.1 Cascio, MG; Gauson, LA; Stevenson, LA; Ross, RA; Pertwee, RG (2010). "Evidence that the plant cannabinoid cannabigerol is a highly potent α2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist". British Journal of Pharmacology. 159 (1): 129–41. doi:10.1111/j.1476-5381.2009.00515.x. PMC 2823359. PMID 20002104.
  30. http://globalhealthtimes.com/2019/03/06/scientists-are-making-thc-and-cbd-in-a-lab-without-growing/
  31. Eberhard Breitmaier (2006). Terpenes: Flavors, Fragrances, Pharmaca, Pheromones. Wiley-VCH. doi:10.1002/9783527609949. ISBN 9783527609949.
  32. 32.0 32.1 32.2 32.3 32.4 32.5 32.6 32.7 https://livelovefruit.com/8-non-marijuana-plants-contain-cannabinoids/
  33. https://www.newsweek.com/medical-marijuana-moss-plant-acts-thc-cannabis-1184661
  34. https://hightimes.com/health/science/doctors-orders-put-marijuana-in-your-butt-dont-smoke-it/
  35. https://www.getholistichealth.com/79015/dandelion-root-kill-melanoma-leukemia/
  36. 36.0 36.1 https://en.wikipedia.org/w/index.php?title=Ginger&oldid=925126238
  37. 37.0 37.1 37.2 An K, Zhao D, Wang Z, et al. (2016). "Comparison of different drying methods on Chinese ginger (Zingiber officinale Roscoe): Changes in volatiles, chemical profile, antioxidant properties, and microstructure". Food Chem. 197 (Part B): 1292–300. doi:10.1016/j.foodchem.2015.11.033. PMID 26675871. Cite uses deprecated parameter |displayauthors= (help)
  38. 38.0 38.1 https://en.wikipedia.org/wiki/Ginger#Chemistry
  39. 39.0 39.1 39.2 39.3 39.4 https://www.healthline.com/nutrition/polyphenols
  40. 40.0 40.1 https://livelovefruit.com/top-spirulina-benefits/

1st seen in

  1. http://www.cannabis-med.org/english/studies.htm
  2. 2.0 2.1 2.2 2.3 possibly non-peer reviewed Original list was at "Cannabis research compiled by Jennifer Huse" at brighterbrains.institute and was accessed / poorly ripped on 2019-12-02. As of 2020-07-16 the above URL redirects to a 404 on at the adress https://humanistglobal.charity/cannabis-research-compiled-by-jennifer-huse. This is probably the same Jennifer A. Huse 'How I Kicked Cancer with Cannabis – Article by Jennifer A. Huse' at transhumanist-party.org Credit for compiling these goes to Jennifer Huse, you know who you are. Please send a current URL
  3. https://www.ingentaconnect.com/content/ben/car/2012/00000009/00000004/art00012
  4. 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 https://www.healthline.com/nutrition/11-proven-benefits-of-ginger
  5. 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 5.16 5.17 5.18 5.19 5.20 5.21 5.22 5.23 5.24 5.25 5.26 5.27 5.28 https://www.trueactivist.com/there-are-now-100-scientific-studies-proving-cannabis-cures-cancer/ CC-BY-4.0 https://www.trueactivist.com/there-are-now-100-scientific-studies-proving-cannabis-cures-cancer/ Source found via Suomen Kannabisyhdistys original post by Eva (you know who you are) in Suomen kannabisfoorumi facebook page on. Found on 2019-11-10
  6. https://www.facebook.com/RxleafMD/posts/1216835445411745
  7. Searching on search engine for fulltext or even an abstract of https://www.healtheuropa.eu/successful-initial-results-using-cannabis-terpenes-to-treat-covid-19/101986/
  8. 8.0 8.1 https://calgary.ctvnews.ca/medicinal-cannabis-mouthwash-could-help-combat-covid-19-1.5294988
  9. 9.0 9.1 9.2 https://thefreshtoast.com/news/study-cannabis-might-prevent-covid-19-infections/
  10. https://www.chicagotribune.com/marijuana/sns-tft-cbd-coronavirus-treatment-research-20200709-4gp2a2w76fah7p277n3ss42yby-story.html
  11. Only peer-reviewed science Original list was at "Cannabis research compiled by Jennifer Huse" at brighterbrains.institute and was accessed / poorly ripped on 2019-12-02. As of 2020-07-16 the above URL redirects to a 404 on at the adress https://humanistglobal.charity/cannabis-research-compiled-by-jennifer-huse. This is probably the same Jennifer A. Huse 'How I Kicked Cancer with Cannabis – Article by Jennifer A. Huse' at transhumanist-party.org Credit for compiling these goes to Jennifer Huse, you know who you are. Please send a current URL

Archiving

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