Revision as of 10:04, 14 October 2018

Nature provides us with many healing agents but these are often pushed to the periphery of public knowledge to ensure big pharma profits.

Blackberries

Ripe, ripening and raw blackberries

Blackberries kill antibiotic resistant staphylococcus aureus bacteria. Irish teen awarded prize for discovery.^[1]

Cannabis

Female Cannabis indica plants. These are often good for pain relief producing a nice body stone.

Cannabis is the oldest and most versatile medicine known to humankind.

Cannabis sativa and Cannabis indica are the main cannabis variants though most strains are mixes of these. A third cannabis line is the Cannabis ruderalis, a rugged northern cannabis that has adapted to flower even under northern long summer days.

The endocannabinoid receptors

Main article in wikipedia Endocannabinoid system

Human body contains 2 types of endocannabinoid receptors CB₁ and CB₂.

CB₁ receptors

CB₁ receptors predominantly located in the nervous system, connective tissues, gonads, glands, and organs^[2].

CB₂ receptors

CB₂ receptors, primarily found in the immune system and also present in the spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands, and reproductive organs^[2].

Endocannabinoids

Anandamide, an endogenous ligand of CB₁ and CB₂

Endocannabinoids are produced by our own bodies from Arachidonic acid or Omega-6 fatty acid^[3].

The two main endocannabinoids are Anandamide and 2-AG.

Anandamide

Anandamide was discovered in 1992 and it binds to both CB₁ and CB₂ receptors. The name comes from the Sanskrit word 'Ananda' meaning 'bliss' and amide from its chemistry.

It has been referred to as the endocannabinoid version of THC.

Herb.co on Anandamide

2-AG

2-Arachidonoylglycerol (2-AG) is an endogenous agonist of the CB₁ receptor.

2-Arachidonoylglycerol aka. 2-AG was discovered in 1994-1995.

Links about 2-AG

Herb.co article on 2-AG

N-Arachidonoyl dopamine

N-Arachidonoyl dopamine discovered in 2000.

2-Arachidonyl glyceryl ether

2-Arachidonyl glyceryl ether discovered in 2001.

Virodhamine

Virodhamine discovered in 2002

Lysophosphatidylinositol

Lysophosphatidylinositol is a contender to be the 6th endocannabinoid.

Phytocannabinoids

Many people may know the 2 most prevalent phytocannabinoids, THC and CBD.

High Times article on cannabinoids

List of known phytocannabinoids from Wikipedia:

THC (Tetrahydrocannabinol)
THCA (Tetrahydrocannbinolic acid)
CBD (Cannabidiol)
CBDA (Cannabidiolic Acid)
CBN (Cannabinol)
CBG (Cannabigerol)
CBC (Cannabichromene)
CBL (Cannabicyclol)
CBV (Cannabivarin)
THCV (Tetrahydrocannabivarin)
CBDV (Cannabidivarin)
CBCV (Cannabichromevarin)
CBGV (Cannabigerovarin)
CBGM (Cannabigerol Monomethyl Ether)
CBE (Cannabielsoin)
CBT (Cannabicitran)

THC

Tetrahydrocannabinol is a partial agonist of CB₁ located mainly in the central nervous system, and the CB₂ receptor mainly expressed in cells of the immune system.

Tetrahydrocannabinol was found in 1964^[4] and it is the main psychoactive compound that brings the 'high' most recreational users are chasing.

THCA

Tetrahydrocannabinolic acid THCA is the what cannabis plants produce to fend off insects from harming it. In pure form THCA is a clear translucent crystalline of white color.

THC is produced from the raw THCA by a process called decarboxylation. Basically means to heat the stuff over certain temperature.

THCA found in raw marijuana apparently has some health enhancing properties. The issue is being researched.

http://herb.co/2017/09/13/raw-weed-benefits/

CBD

Cannabidiol has very low affinity for the cannabinoid CB₁ and CB₂ receptors receptors but acts as an indirect antagonist of cannabinoid agonists.

Cannabidiol and it was isolated and identified from Cannabis sativa in 1940^[4]. CBD is not psychoactive and it has the most medical applications of all phytocannabinoids.

“Cannabidiol has little affinity for CB₁ and CB₂ receptors but acts as an indirect antagonist of cannabinoid agonists.^[5]”
~ Wikipedia on Cannabidiol

CBDA

Cannabidiolic Acid is the raw form. Decarboxylating CBDA yields CBD.

http://herb.co/2017/05/20/cbda/

CBN

Cannabinol

CBG

Cannabigerol

“Cannabigerol has been shown to promote apoptosis in cancer cells and inhibit tumor growth in mice. It acts as an α₂-adrenergic receptor agonist, 5-HT_1A receptor antagonist, and CB₁ receptor antagonist.^[6] It also binds to the CB₂ receptor.^[6]”
~ Wikipedia on Cannabigerol

THCV

Tetrahydrocannabivarin can be used to inhibit appetite.

Links about THCV

http://herb.co/2017/04/14/tetrahydrocannabivarin-thcv/

CBDV

Cannabidivarin

CBCV

Cannabichromevarin

CBGV

Cannabigerovarin

CBGM

Cannabigerol Monomethyl Ether

CBE

Cannabielsoin

CBT

Cannabicitran

Cannabis therapeutics

Rare 11-leafer Cannabis sativa

Male Cannabis sativa plants in late flowering stages.

Cannabis can be applied to treat a wide assortment of illnesses. In this case it is called medical cannabis.

Due to the inbuilt default to always take the safe route and also to backup the back of your fellow MD colleague the Wikipedia does not yield the right infos on how useful and versatile a medication cannabis is.

Research has been held back by arcane laws even as cannabis is the oldest medicine known to man and it should be gladly appreciated and not outlawed because of big pharma interests.

Alzheimer's disease and cannabis

Cannabis has been found to be beneficial for Alzheimer's sufferers. Especially true this is for THC which inhibits the formulation of toxic beta amyloid protein plaque on braincells which causes Alzheimer's disease.

News (2016): "Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells" @ salk.edu - Preliminary lab studies at the Salk Institute find THC reduces beta amyloid proteins in human neurons
Wikipedia article on Alzheimer's disease research has only a few words about cannabis therapeutics and those are very sceptical.

Amyotrophic lateral sclerosis and cannabis

Cannabis helps with Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig's disease and motor neurone disease (MND).

http://herb.co/2017/02/01/cannabis-lou-gehrigs-disease-als/

Asthma and cannabis

http://herb.co/2017/01/11/cannabis-asthama/

Autism and cannabis

Autoimmune diseases and cannabis

Cannabis helps with many autoimmune diseases due to its anti-inflammatory and other properties.

Links about autoimmune diseases and cannabis

http://herb.co/2016/10/04/autoimmune-diseases/

Rheumatoid arthritis and cannabis

Cannabis helps with Rheumatoid arthritis.

Links about Rheumatoid arthritis and cannabis

http://herb.co/2016/08/06/arthritis-pain-inflammation/

Lupus and cannabis

Cannabis helps with Systemic lupus erythematosus

http://herb.co/2016/05/15/cannabis-vs-lupus/

Coeliac disease and cannabis

Cannabis helps with Coeliac disease.

http://herb.co/2016/02/12/celiac-disease-and-cannabis/

Psoriasis and cannabis

Cannabis helps with Psoriasis when applied externally.

http://herb.co/2016/05/28/skin-deep-psoriasis/

Type 1 diabetes and cannabis

http://herb.co/2015/11/17/marijuana-and-diabetes/

Multiple sclerosis (MS) and cannabis

Cannabis is very good against Multiple sclerosis.

Cancers and cannabis

Key things everyone needs to know about cancers and cannabis

Warning: Smoking the cannabis as the method of cannabinoid delivery the smoke contains quite a few carcinogenic substances i.e. cancer inducing substances.

Advice: There are various other methods to consumer cannabis e.g. vaping, a method where the plant material is heated hot enough for the cannabinoids to become gaseous but cold enough that the plant matter does not combust and thus avoiding the carcinogens that come from burning the plant matter.

Internet is rife with stories about winning the battle against cancer with the help of phytocannabinoids. What does the science say?

Cannabis is...

Anti-proliferative - cannabis is against tumor growth ^[7]
Anti-metastatic - cannabis is against cancer spreading to other parts in the body because of metastatic activity^[7]
Anti-angiogenetic - cannabis is against new blood vein growth to tumor^[7]
Apoptotic - cannabis causes cancer cells to programmedly kill themselves via Apoptosis. ^[7]
Pain relief - cannabis works very well against the somatic and nonsomatic pains brought on by cancer.
Appetite stimulator - cannabis helps maintain a good appetite.
Anti-nauseatic - cannabis helps with the chemotherapy-induced nausea and vomiting. ^[8] if you receive chemotherapy.

Phytocannabinoids are harmless to healthy cannabinoid receptor containing cells.

Links about cannabis and cancer in general

"Official" information

Cannabis and cancers advocacy

Testimonies about cannabis and cancer

Dr. Mark Sircus, Ac., OMD on cannabis curing cancer

Scientific studies about cannabis and cancers in general

Anticancer mechanisms of cannabinoids

Learn from videos by experts in phytocannabinoid treatment of cancers

Info: Cristina Sánchez is a molecular biology research scientist who did her doctorate on cannabinoids and cancers. She is the leader of all time in researching the anti-cancer qualities of cannabinoids. Another molecular biology researcher working on researching the potential of cannabis as a cancer medication in the Compultense University of Madrid is Dr. Manuel Guzmán

Videos

See also: Cancers and turmeric (intra-article link)

Leukemia and cannabis

There are 2 main types of Leukemia:

Myeloid leukemia (of the bone marrow)
Lymphoid leukemia (of the lymphatic node)

Links about Lympoid and Myeloid leukemia and cannabis

Dronabinol (synthetic THC) has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns

Links about Lymphoid leukemia and cannabis

Links about Myeloid leukemia and cannabis

Prostate cancer and cannabis

Cannabis helps with prostate cancer.

herb.co/2017/01/13/prostate-cancer-cannabis/

Brain cancer and cannabis

Crohn's disease and cannabis

Study shows THC helps with Crohn's disease.

Epilepsy and cannabis

Full extract cannabis oil in a syringe for easy dosing and travel is usually administered in drops to the gums or under the tongue.

Cannabis can be used to treat epilepsy.

http://sorendreier.com/boy-with-100-seizures-a-day-now-has-none-after-taking-cannabis-oil/

Migraines and cannabis

It has been suggested that clinical endocannabinoid deficiency syndrome (CEDS) may be causing migraines. Many studies found medical cannabis as an effective prophylaxis against migraine attacks, especially the high CBD strains.

CBD Testers article on treating migraines with medical cannabis and link to the study 'Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population' at PubMed that the article is talking about.
Abstracts of studies on migraines and medical cannabis at migrainebuds.com

Pain treatment with cannabis

“You just don't feel like thinking about the pain.”
~ Apotheker Jukeboksi on somatic pain relief with cannabis

“There is more to it than that.”
~ Science on above quote

Cannabis is anti-inflammatory which helps relieve some of the pain. Pain is a signal of inflammation so counter-acting inflammation causing things cannabis naturally helps lower the pain.

Parkinsons disease and cannabis

https://herb.co/marijuana/news/cannabis-and-parkinsons-disease

Non-somatic issues with cannabis

Cannabis can help with various non-somatic problems such as psychiatry, depression and PTSD.

PTSD and cannabis

https://www.leafly.com/news/health/cannabis-and-post-traumatic-stress-disorder-ptsd

External links about cannabis as medicine

http://www.calgarycmmc.com/ a large compendium on medical cannabis sorted alphabetically by ailment.
http://www.cannabisconnections.tk/2018/03/700-medicinal-uses-of-cannabis-sorted.html
http://www.encod.org/info/700-MEDICINAL-USES-OF-CANNABIS.html
http://expand-your-consciousness.com/100-scientific-studies-agree-cannabis-annihilates-cancer/ about 100 nig.gov studies linked some cases briefly described.
71 medical uses of cannabis compiled by LearnGreenFlower.com

Literature about cannabis as a medicine

MARIJUANA AS MEDICINE? The Science Beyond the Controversy, a book published in 2000 that you can read on-line from The National Academies Press .

Pineapple

Pineapple is effective cough medicine due to its Bromelain content.

Pineapple fruit and it's stem contain Bromelain, an enzyme with anti-cough properties.

In vitro and in vivo studies demonstrate that bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities.^[9] Bromelain accounts for many therapeutic benefits like the treatment of angina pectoris, bronchitis, sinusitis, surgical trauma, and thrombophlebitis, debridement of wounds, and enhanced absorption of drugs, particularly antibiotics.^[9]

Stevia

Stevia rebaudiana

Stevia works against the Lyme disease.^[10]

Turmeric

Turmeric (Curcuma Longa) of genus Curcuma.

Turmeric, used as spice, medicine and dye is made of ground roots of Curcuma Longa.

Turmeric contains curcumin, a curcuminoid.

Cancers and turmeric

Curcumin has been found to have anti-cancer properties. Curcumin interferes with cancer via multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation^[11].

See also: Cancers and cannabis (intra-article link)

Alzheimer's and turmeric

Optimized Turmeric Extract Reduces β-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer’s Transgenic Mice suggests that turmeric may be useful for Alzheimer's sufferers as it has been shown to inhibit beta amyloid aggregation and secretation in mice.

See also: Alzheimer's and cannabis (intra-article link)

Information sources on natural therapeutics

References

↑ http://theorganicdream.com/2018/02/irish-teen-awarded-prestigious-prize-discovery-natural-substance-kills-antibiotic-resistant-bacteria/
↑ ^2.0 ^2.1 https://patients4medicalmarijuana.wordpress.com/2017/07/06/how-and-why-your-brain-makes-its-own-cannabinoids/
↑ https://wakeup-world.com/2014/09/08/the-endocannabinoid-system-and-how-thc-cures-cancer/
↑ ^4.0 ^4.1 https://en.wikipedia.org/wiki/Tetrahydrocannabinol
↑ Mechoulam, Raphael; Peters, Maximilian; Murillo-Rodriguez, Eric; Hanuš, Lumír O. (2007). "Cannabidiol – Recent Advances". Chemistry & Biodiversity. 4 (8): 1678–92. doi:10.1002/cbdv.200790147. PMID 17712814.
↑ ^6.0 ^6.1 Cascio, MG; Gauson, LA; Stevenson, LA; Ross, RA; Pertwee, RG (2010). "Evidence that the plant cannabinoid cannabigerol is a highly potent α2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist". British Journal of Pharmacology. 159 (1): 129–41. doi:10.1111/j.1476-5381.2009.00515.x. PMC 2823359. PMID 20002104.
↑ ^7.0 ^7.1 ^7.2 ^7.3 https://herb.co/news/health/cannabis-kills-cancer/
↑ http://herb.co/2017/01/03/cannabis-chemotherapy-induced-nausea/
↑ ^9.0 ^9.1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529416/
↑ https://www.healthspiritbody.com/lyme-disease-treatment/
↑ https://www.sciencedirect.com/science/article/pii/S0304383508002310

[blackberries1-1] ttp://theorganicdream.com/2018/02/irish-teen-awarded-prestigious-prize-discovery-natural-substance-kills-antibiotic-resistant-bacteria/

[p4mm-2] 2.0 ^2.1 https://patients4medicalmarijuana.wordpress.com/2017/07/06/how-and-why-your-brain-makes-its-own-cannabinoids/

[wakeup-world-com-3] ttps://wakeup-world.com/2014/09/08/the-endocannabinoid-system-and-how-thc-cures-cancer/

[enwiki_thc-4] 4.0 ^4.1 https://en.wikipedia.org/wiki/Tetrahydrocannabinol

[recentadvances-5] Mechoulam, Raphael; Peters, Maximilian; Murillo-Rodriguez, Eric; Hanuš, Lumír O. (2007). "Cannabidiol – Recent Advances". Chemistry & Biodiversity. 4 (8): 1678–92. doi:10.1002/cbdv.200790147. PMID 17712814.

[pmid20002104-6] 6.0 ^6.1 Cascio, MG; Gauson, LA; Stevenson, LA; Ross, RA; Pertwee, RG (2010). "Evidence that the plant cannabinoid cannabigerol is a highly potent α2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist". British Journal of Pharmacology. 159 (1): 129–41. doi:10.1111/j.1476-5381.2009.00515.x. PMC 2823359. PMID 20002104.

[herb-co-cancer-7] 7.0 ^7.1 ^7.2 ^7.3 https://herb.co/news/health/cannabis-kills-cancer/

[herb-co-nausea-8] ttp://herb.co/2017/01/03/cannabis-chemotherapy-induced-nausea/

[Bromelain1-9] 9.0 ^9.1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529416/

[10] ttps://www.healthspiritbody.com/lyme-disease-treatment/

[11] ttps://www.sciencedirect.com/science/article/pii/S0304383508002310

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@@ Line 293: / Line 293: @@
 '''Learn from videos by experts in phytocannabinoid treatment of cancers'''
-'''Info:''' '''[[w:Cristina Sánchez (molecular biologist)|Cristina Sánchez]]''' is a molecular biology research scientist who did her doctorate on cannabinoids and cancers. She is the leader of all time in researching the anti-cancer qualities of cannabinoids.
+'''Info:''' '''[[w:Cristina Sánchez (molecular biologist)|Cristina Sánchez]]''' is a molecular biology research scientist who did her doctorate on cannabinoids and cancers. She is the leader of all time in researching the anti-cancer qualities of cannabinoids. Another molecular biology researcher working on researching the potential of cannabis as a cancer medication in the Compultense University of Madrid is [http://www.bbm1.ucm.es/cannabis/manuelguzmaninicio_en.htm Dr. Manuel Guzmán]
 '''Videos'''
@@ Line 300: / Line 300: @@
 * [https://www.youtube.com/watch?v=ccYeiuzFnYs Dr. Cristina Sanchez at Cannafest Prague 2015]
 * [https://www.youtube.com/watch?v=W53Z33Vk5T8 Dr. Cristina Sanchez lecture in Australia] (no slideshow shots, sorry)
 '''See also: [[#Cancers and turmeric|Cancers and turmeric]]''' (intra-article link)