User:Jukeboksi/Wiki.study/Natural therapeutics

Cannabis is the oldest and most versatile medicine known to man.

Rare 11-leafer Cannabis sativa

Endocannabinoid system

Main article in wikipedia Endocannabinoid system

Endocannabinoids

Anandamide, an endogenous ligand of CB₁ and CB₂

Endocannabinoids are produced by our own bodies.

• Anandamide was discovered in 1992.
• AG-2 was discovered in 1994-1995.
• N-Arachidonoyl dopamine discovered in 2000.
• 2-Arachidonyl glyceryl ether discovered in 2001.
• Virodhamine discovered in 2002
• Lysophosphatidylinositol is a contender to be the 6th endocannabinoid.

Endocannabinoid receptors

Human cells may have either of 2 types of endocannabinoid receptors CB1 and CB2. These receptors are present also in cells far away from the brain.

Cannabis

A lovely female Cannabis indica. These are often good for pain relief producing a nice body stone.

Cannabis sativa and Cannabis indica are the main cannabis variants though most strains are mixes of these. A third cannabis line is the Cannabis ruderalis, a rugged nothern cannabis that has adapted to flower even under northern long summer days.

Exocannabinoids

Tetrahydrocannabinol

Many people may know the 2 most prevalent exocannabinoids, THC and CBD.

THC is produced from the raw THCA by a process called de-carboxylation. Basically means to heat the stuff over certain temperature.

THC is the psychoactive compound that brings the 'high' most recreational users are chasing but CBD has the most medical applications.

Full list of known exocannabinoids from Wikipedia:

• THC (Tetrahydrocannabinol)
• THCA (Tetrahydrocannbinolic acid)
• CBD (Cannabidiol)
• CBDA (Cannabidiolic Acid)
• CBN ((Cannabinol)
• CBG (Cannabigerol)
• CBC (Cannabichromene)
• CBL (Cannabicyclol)
• CBV (Cannabivarin)
• THCV (Tetrahydrocannabivarin)
• CBDV (Cannabidivarin)
• CBCV (Cannabichromevarin)
• CBGV (Cannabigerovarin)
• CBGM (Cannabigerol Monomethyl Ether)
• CBE (Cannabielsoin)
• CBT (Cannabicitran)

Treating somatic issues

Cannabis can be applied to treat a wide assortment of illnesses. In this case it is called medical cannabis.

Pain treatment

“You just don't feel like thinking about the pain.”

~ Apotheker Jukeboksi on somatic pain relief with cannabis

“There is more to it than that.”

~ Science on above quote

Exocannabinoid treatment of cancers

Full extract cannabis oil in a syringe for easy dosing and travel is usually administered in drops to the gums or under the tongue.

Internet is rife with stories about winning the battle against cancer with the help of exocannabinoids. What does the science say?

4 points how cannabis works against cancer compiled by herb.co

1. Anti-proliferative - cannabis is against tumor growth
2. Anti-metastatic - cannabis is against cancer spreading to other parts in the body because of metastatic activity
3. Anti-angiogenetic - cannabis is against new blood vein growth to tumor
4. Apoptotic - cannabis causes cancer cells to programmedly kill themselves (Apoptosis).

Exocannabinoids are harmless to healthy cannabinoid receptor containing cells.

Additionally anecdotally true are

1. Cannabis works very well against the somatic and nonsomatic pains brought on by cancer
2. Cannabis can help maintain a good appetite, chemo or no chemo.

On the Internet about exocannabinoid treatment of cancers

• http://www.calgarycmmc.com/c.htm index into studies about the health benefits of cannabis, letter 'c' lists cancers for which studies have been done.

• Dr. Cristina Sanchez interview where she expains how apoptosis makes cancer cells kill themselves (a molecular biology research scientist who did her doctorates on exocannabinoids and cancers)
• Dr. Cristina Sanchez on how cannabinoids work against cancers
• Dr. Cristina Sanchez at Cannafest Prague 2015
• Dr. Cristina Sanchez lecture in Australia (no slideshow shots, sorry)

Treating non-somatic issues

Cannabis can help with various non-somatic problems such as depression and PTSD.

External links

• http://www.calgarycmmc.com/ a large compendium on medical cannabis sorted alphabetically by ailment.