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= Alzheimer's = == Alzheimer's and cannabis == [[File:Amyloid-beta.png|thumb|right|300px|Modeled is the toxic [[w:Amyloid beta|β-amyloid]] transmembrane protein structure.]] [[File:Cannabis sativa kz05.jpg|thumb|right|300px|[[w:Cannabis sativa|Cannabis sativa]] seedling in Poland could use a little water.]] Cannabis has been found beneficial to [[w:Alzheimer's disease]] sufferers. This is strongly supported by in-vivo i.e. animal "model" studies, where they cause a similar disease in the test animals and then try different substances on them and see which ones are doing well and which ones are not. It would seem that [[w:Tetrahydrocannabinol]] (THC) is better than any other chemical we know at inhibiting the formation of toxic [[w:Amyloid beta|beta]] [[w:amyloid|amyloid]] protein plaque on braincells which causes the deteriation in Alzheimer's disease, but have a look yourself. (own assesment based on abstracts of in-vivo studies and reporting) See '''[[#Cannabis therapeutics]]''' for list of other illnesses that cannabis looks to work against. ---- ''' Scientific research about Alzheimer's and cannabis ''' (in reverse chronology) * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234911/ ''''''Potential and Limits of Cannabinoids in Alzheimer’s Disease Therapy'''''' at ncbi.nlm.nih.gov], a '''2021''' review published in [[w:Biology (journal)]] * [https://pubmed.ncbi.nlm.nih.gov/33612548/ ''''''Cannabidiol Ameliorates Cognitive Function via Regulation of IL-33 and TREM2 Upregulation in a Murine Model of Alzheimer's Disease'''''' at pubmed.ncbi.nlm.nih.gov], a '''2021''' study by researchers from [[w:Augusta University]] on CBD and and its effects on the [[w:TREM2]] and [[w:Interleukin 33]] proteins in Alzheimer's disease published in [[w:Journal of Alzheimer's Disease]] - "'' Our findings suggest that CBD treatment enhanced IL-33 and TREM2 expression, ameliorated the symptoms of AD, and retarded cognitive decline. ''" (ending sentence of the abstract) ** Reporting [https://www.sciencedaily.com/releases/2021/03/210309192548.htm ''''''CBD reduces plaque, improves cognition in model of familial Alzheimer's'''''' at sciencedaily.com] from [https://jagwire.augusta.edu/cbd-reduces-plaque-improves-cognition-in-model-of-familial-alzheimers/ ''''''CBD reduces plaque, improves cognition in model of familial Alzheimer’s'''''' at jagwire.augusta.edu] 2021 * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970569/ ''''''A Review on Studies of Marijuana for Alzheimer’s Disease – Focusing on CBD, THC'''''' at ncbi.nlm.nih.gov], a '''2019''' literature review published in the [https://www.journal-jop.org/main.html Journal of Pharmacopuncture (JoP)] - "''These results implied that the CBD components of cannabis might be useful to treat and prevent AD because CBD components could suppress the main causal factors of AD. Moreover, it was suggested that using CBD and THC together could be more useful than using CBD or THC alone.''" (results section) * [https://www.frontiersin.org/articles/10.3389/fnint.2018.00051/full#h6 ''''''Cannabis Therapeutics and the Future of Neurology: Cannabis and Alzheimer Disease (AD)''''''], a '''2018''' perspectives article published in Frontiers in Integrative Neuroscience. * [https://www.nature.com/articles/nm.4311 '''''A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice'''''' at nature.com], a '''2017''' joint study by German and Israeli scientists from the [[w:University of Bonn]] and the [[w:Hebrew University of Jerusalem]] published in [[w:Nature Medicine]]. ** [https://www.sciencedaily.com/releases/2017/05/170508112400.htm ''''''Cannabis reverses aging processes in the brain, study suggests'''''' at sciencedaily.com], 2017 reporting on the study ** [https://www.jpost.com/business-and-innovation/health-and-science/cannabis-may-offer-cure-for-dementia-study-finds-490233 ''''''Cannabis may offer cure for dementia, study finds'''''' at jpost.com], 2017 reporting on the study * [https://www.nature.com/articles/npjamd201612 ''''''Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids'''''' at nature.com], a '''2016''' open access research article by researchers from the [[w:Salk Institute]] and [[w:University of California, San Diego]] published in '''npj Aging and Mechanisms of Disease''' finds THC reduces beta amyloid proteins in human neurons. ** [https://www.salk.edu/news-release/cannabinoids-remove-plaque-forming-alzheimers-proteins-from-brain-cells/ ''''''Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells'''''' at salk.edu], 2016 preliminary reporting on the Salk Institute study. * [https://pubmed.ncbi.nlm.nih.gov/26757043/ ''''''Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia: An-Open Label, Add-On, Pilot Study'''''' at pubmed.ncbi.nlm.nih.gov]<ref group="1st seen in">http://www.cannabis-med.org/english/studies.htm</ref>, a '''2016''' study published in the [[w:Journal of Alzheimer's Disease]] * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562334/ ''''''A Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology'''''' at ncbi.nlm.nih.gov], a '''2008''' study published in [[w:Molecular Pharmacology]] - ''Compared to currently approved drugs prescribed for the treatment of Alzheimer's disease, THC is a considerably superior inhibitor of Aβ aggregation, and this study provides '''a previously unrecognized molecular mechanism''' through which cannabinoid molecules may directly impact the progression of this debilitating disease.'' (excerpt from the abstract) * [http://www.jneurosci.org/cgi/content/abstract/25/8/1904 ''''''Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation'''''' at jneurosci.org]<ref group="1st seen in" name="Jennifer A. Huse medical cannabis research list including non-scientific"/>, a '''2005''' study by Madrid's [[w:Complutense University]] and the [[w:Cajal Institute]] published in [[w:Journal of Neuroscience]]. ** [http://www.mapinc.org/drugnews/v05/n307/a10.html ''''''Europe: Study: Marijuana Slows Alzheimer's Decline'''''' at mapinc.org]<ref group="1st seen in" name="Jennifer A. Huse medical cannabis research list including non-scientific"/>, 2005 reporting on the study ** [http://news.bbc.co.uk/2/hi/health/4286435.stm ''''''Marijuana may block Alzheimer's '''''' at news.bbc.co.uk]<ref group="1st seen in" name="Jennifer A. Huse medical cannabis research list including non-scientific"/>, 2005 reporting on the study ** [http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=187#1 ''''''IACM-Bulletin: Science: Cannabinoids reduce the progression of Alzheimer's disease in animals'''''' at cannabis-med.org], 2005 reporting on the study ''' Links about Alzheimer's disease and cannabis''' * [https://livelovefruit.com/cannabis-for-alzheimers/ ''''''Cannabis Compounds Found to Remove Toxic Alzheimer’s Proteins From the Brain'''''' at livelovefruit.com] - 2018 reporting, updated 2019 * [https://www.forbes.com/sites/abbierosner/2019/02/26/cannabis-for-parkinsons-and-alzheimers-diseases-an-interview-with-dr-ethan-russo/#10fc5c765dd6 ''''''Cannabis For Parkinson's And Alzheimer's Diseases -An Interview With Dr. Ethan Russo'''''' at forbes.com], a 2019 interview * [[w:Alzheimer's disease research|'''Alzheimer's disease research''' at en.wikipedia.org]] has only a few words about cannabis therapeutics and those are very sceptical. == Alzheimer's and turmeric == [[File:Curcuma_longa201608JAPAN.jpg|thumb|200px|[[w:Turmeric|Turmeric]] (Curcuma Longa) of genus [[w:Curcuma|Curcuma]].]] * [https://www.fortunejournals.com/articles/the-effects-of-turmeric-on-alzheimerrsquos-patients.html ''''''The Effects of Turmeric on Alzheimer’s Patients'''''' at fortunejournals.com], a 2019 study published in the open-access [https://www.fortunejournals.com/journal-of-food-science-and-nutrition-research-home-fjfsnr.php Journal of Food Science and Nutrition Research by Fortune Journals] * [https://www.sciencedirect.com/science/article/pii/S000689931930530X ''''''The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies'''''' at sciencedirect.com], a '''2019''' systematic review published in [[w:Brain Research]] * [https://www.eurekaselect.com/97560/article ''''''Optimized Turmeric Extract Reduces β-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer’s Transgenic Mice'''''' at eurekaselect.com]<ref group="1st seen in" name="AlzheimersTurmeric2012">https://www.ingentaconnect.com/content/ben/car/2012/00000009/00000004/art00012</ref>, a '''2012''' study published in [[w:Current Alzheimer Research]]. The study suggests that turmeric may be useful for Alzheimer's sufferers as it has been shown to inhibit beta amyloid aggregation and secretation in mice. * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665200/ ''''''Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms of dementia'''''' at ncbi.nlm.nih.gov], a '''2012''' case report on 3 patients with Alzheimer's disease published in [https://www.ayujournal.org/ AYU (An International Quarterly Journal of Research in Ayurveda)] - ''The present cases suggest a significant improvement of the behavioral symptoms in the AD with the turmeric treatment, leading to probable benefit of the use of turmeric in individuals with the AD with Behavioral and Psychological Symptoms of Dementia (BPSD).'' (ending sentence of the abstract) * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781139/ ''''''The effect of curcumin (turmeric) on Alzheimer's disease: An overview'''''' at ncbi.nlm.nih.gov], a '''2008''' overview article published in the [[w:Annals of Indian Academy of Neurology]] ''' Links about Alzheimer's disease and turmeric''' * [https://www.alzheimersorganization.org/turmeric-curcumin-and-alzheimers ''''''Turmeric Curcumin and Alzheimer's Disease'''''' at alzheimersorganization.org] * [https://www.verywellhealth.com/turmeric-for-alzheimers-disease-88602 ''''''Turmeric for Alzheimer's Disease'''''' at verywellhealth.com] == Alzheimer's and ginger == [[File:Ginger Plant vs.jpg|thumb|right|260px|[[w:Ginger|Ginger]] plant]] Ginger may improve brain functioning and protect against Alzheimer's disease <ref group="1st seen in" name="healthline-ginger2017"/> * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470323/ ''''''Ginger, a Possible Candidate for the Treatment of Dementias?'''''' at ncbi.nlm.nih.gov], a '''2021''' literature review published in [[w:Molecules (journal)]] * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211852/ ''''''Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer’s drugs: a computational investigation'''''' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="healthline-ginger2017"/>, a 2014 study published in [[w:Drug Design, Development and Therapy]] * [https://pubmed.ncbi.nlm.nih.gov/23374025/ ''''''Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats'''''' at pubmed.ncbi.nlm.nih.gov]<ref group="1st seen in" name="healthline-ginger2017"/>, a 2013 study published in [[w:Rejuvenation Research]] * [https://pubmed.ncbi.nlm.nih.gov/20952170/ ''''''Inhibition of acetylcholinesterase activities and some pro-oxidant induced lipid peroxidation in rat brain by two varieties of ginger (Zingiber officinale)'''''' at pubmed.ncbi.nlm.nih.gov]<ref group="1st seen in" name="healthline-ginger2017"/>, a 2012 study published in [https://www.journals.elsevier.com/experimental-and-toxicologic-pathology Experimental and Toxicologic Pathology] ----
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