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=== Brain cancer and cannabis === In '''2018''' [[w:Insys Therapeutics|Insys Therapeutics]] announced the the [[w:Food and Drug Administration|FDA]] has given CBD an [[w:orphan drug|orphan drug]] designation (ODD) to CBD for treating gliomas.<ref name="WPHealth2018glioma">https://web.archive.org/web/20181229083812/https://www.wphealth.cc/2018/10/11/fda-approves-cannabis-for-brain-cancer-treatment/ last working archive for that webpage</ref> ''' Studies about brain tumors and cannabis ''' * [https://pubmed.ncbi.nlm.nih.gov/34918964/ ''''''Inhalant Cannabidiol Inhibits Glioblastoma Progression Through Regulation of Tumor Microenvironment'''''' at pubmed.ncbi.nlm.nih.gov], a 2021 in-vivo study on the effects of CBD on glioblastomas published in [[w:Cannabis and Cannabinoid Research]]<ref group="1st seen in">https://jagwire.augusta.edu/cbd-reduces-glioblastomas-size-supportive-environment-in-experimental-model/</ref> ** https://jagwire.augusta.edu/cbd-reduces-glioblastomas-size-supportive-environment-in-experimental-model/ reporting * [https://www.proquest.com/openview/58d8e60e4aa4a7a2ce8b78fb17f6733d/ ''''''Cannabigerol Is a Potential Therapeutic Agent in a Novel Combined Therapy for Glioblastoma'''''' at proquest.com]<ref group="1st seen in" name="RXLeafGlioma2021">https://www.facebook.com/RxleafMD/posts/1216835445411745</ref>, a 2021 study published in [[w:Cell (journal)]] regarding the efficacy of combining [[#CBG]] ([[w:Cannabigerol]]) with other medication against gliomas. * [https://www.frontiersin.org/articles/10.3389/fnint.2018.00051/full#h4 'Cannabis Therapeutics and the Future of Neurology: Cannabis and Brain Tumors' at FrontiersIn.org], a '''2018''' '''perspective article''' published in Frontiers in Integrative Neuroscience by [[w:Frontiers Media]] * [https://www.ncbi.nlm.nih.gov/pubmed/20307616 'Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2010''' '''comparative study''', published in [[w:Neurochemistry International]] * [https://www.ncbi.nlm.nih.gov/pubmed/20090845 'The expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomas' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2010''' study published in [[w:PLOS One]] on [[w:astrocytomas]] and cannabis receptors * [https://www.ncbi.nlm.nih.gov/pubmed/17675107 'Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity?' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2009''' '''clinical trial''', published in [[w:Neuropharmacology (journal)]] * [https://www.ncbi.nlm.nih.gov/pubmed/19480992 'Predominant CB2 receptor expression in endothelial cells of glioblastoma in humans' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2009''' study, published in [[w:Brain Research Bulletin]] * [https://www.ncbi.nlm.nih.gov/pubmed/19229996 'Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2009''' study, published in [[w:Glia (journal)]] * [https://www.ncbi.nlm.nih.gov/pubmed/19425170 'Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2009''' study, published in [[w:Journal of Clinical Investigation]] * [https://www.ncbi.nlm.nih.gov/pubmed/18088200 'Cannabinoids as potential new therapy for the treatment of gliomas' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2008''' '''review''', published in ''Expert review on neurotherapies'' * [https://www.ncbi.nlm.nih.gov/pubmed/18615640 'High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2008''' study published in [[w:Journal of Neuroscience Research]] * [https://www.ncbi.nlm.nih.gov/pubmed/18339876 'Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2008''' study, published in [[w:Cancer Research (journal)]] * [https://www.ncbi.nlm.nih.gov/pubmed/17952650 'Cannabinoids and gliomas' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2007''' '''review''', published in [[w:Molecular Neurobiology (journal)]] * [https://www.ncbi.nlm.nih.gov/pubmed/17202146 'Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2007''' study, published in [[w:Journal of Biological Chemistry]] * [https://www.ncbi.nlm.nih.gov/pubmed/16893424 'Cannabinoid receptors in human astroglial tumors' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2006''' study published in [[w:Journal of Neurochemistry]] * [https://www.ncbi.nlm.nih.gov/pubmed/16909207 'The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2006''' study published in [[w:Cellular and Molecular Life Sciences]] * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576089 'Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, '''2005''' study, published in [[w:British Journal of Pharmacology]] * [https://www.ncbi.nlm.nih.gov/pubmed/15453094 'Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2004''' study, published in [[w:Journal of Neuropathology & Experimental Neurology]] * [https://www.ncbi.nlm.nih.gov/pubmed/15313899 'Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2004''' study, published in [[w:Cancer Research (journal)]] * [https://www.ncbi.nlm.nih.gov/pubmed/15275820 'Hypothesis: cannabinoid therapy for the treatment of gliomas?' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2004''' '''review''', published in [[w:Neuropharmacology (journal)]] * [https://www.ncbi.nlm.nih.gov/pubmed/14617682 'Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2004''' study, published in [[w:Journal of Pharmacology and Experimental Therapeutics]] * [https://www.ncbi.nlm.nih.gov/pubmed/15361550 'Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2004''' study, published in [[w:Molecular Pharmacology]] * [https://www.ncbi.nlm.nih.gov/pubmed/11479216 'Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''2001''' study published in [[w:Cancer Research (journal)]] * [https://www.ncbi.nlm.nih.gov/pubmed/9771884 'Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells' at ncbi.nlm.nih.gov]<ref group="1st seen in" name="trueactivist.com 2017"/>, a '''1998''' study, published in [[w:FEBS Letters]] ''' Links about brain cancer and cannabis''' * [https://www.calgarycmmc.com/cancerglioma.htm Extensive compendium of research about brain cancer and cannabis at calgarycmmc.com] * https://herb.co/news/health/taylor-rehmeyer/ ----
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