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= Autoimmune diseases = [[File:Joint.svg|thumb|right|300px|A joint]] '''Terminology''' * [[w:Autoimmunity]] is the system of immune responses of an organism against its own healthy cells, tissues and other body normal constituents. * [[w:Autoimmune disease]] is a condition arising from an abnormal [[w:immune response]] to a functioning body part. * [[w:Rheumatology]] (Greek ''ῥεῦμα'', ''rheûma'', flowing current) is a branch of medicine devoted to the [[w:medical diagnosis]] and [[w:therapy]] of [[w:rheumatism|rheumatic diseases]]. * [[w:Rheumatism]]<ref>{{Cite web |last1=Bruce |first1=Debra Fulghum |last2=PhD |title=Rheumatic Diseases: Types, Causes, and Diagnosis |url=https://www.webmd.com/rheumatoid-arthritis/an-overview-of-rheumatic-diseases |access-date=2022-05-10 |website=WebMD |language=en}}</ref> or rheumatic disorders are conditions causing [[w:chronic pain|w:chronic, often intermittent pain]] affecting the [[w:joint]]s or [[w:connective tissue]]. * [[w:Arthritis]] is a term often used to mean any disorder that affects [[w:joint]]s (Wikipedia) * [[w:Rheumatoid arthritis]] ('''RA''') is a long-term [[w:autoimmune disorder]] that primarily affects [[w:synovial joint]]s. * [[w:Rheumatoid factor]] ('''RF''') is the [[w:autoantibody]] that was first found in [[w:rheumatoid arthritis]]. It is defined as an [[w:antibody]] against the [[w:Fragment crystallizable region]] portion of [[w:IgG]] and different RFs can recognize different parts of the IgG-Fc.<ref>{{cite journal|last1=Falkenburg|first1=W.J.J.|title=IgG Subclass Specificity Discriminates Restricted IgM Rheumatoid Factor Responses From More Mature Anti–Citrullinated Protein Antibody–Associated or Isotype-Switched IgA Responses|journal=Arthritis & Rheumatology|date=November 2015|volume=67|issue=12|pages=3124–3134|doi=10.1002/art.39299|pmid=26246004|ref=IgG Subclass Specificity Discriminates Restricted IgM Rheumatoid Factor Responses From More Mature Anti–Citrullinated Protein Antibody–Associated or Isotype-Switched IgA Responses|doi-access=free}}</ref> RF and IgG join to form [[w:immune complex]]es that contribute to the [[w:disease]] process.<ref>{{cite journal |vauthors=Edkins A, Cushley W | year = 2012 | title = The Jekyll and Hyde nature of antibodies | journal = Biological Sciences Review | volume = 25 | issue = 2| page = 4 }}</ref> ([https://en.wikipedia.org/w/index.php?title=Rheumatoid_factor&oldid=1086420200 Wikipedia]) * [[w:Osteoarthritis]] ('''OA''') is a type of degenerative [[w:joint disease]] that results from breakdown of [[w:articular cartilage|articular joint cartilage]] and underlying [[w:bone]]. * [[w:Synovial joint]], also known as '''diarthrosis''', joins bones or cartilage with a fibrous [[w:joint capsule]] that is continuous with the [[w:periosteum]] of the joined bones, constitutes the outer boundary of a synovial cavity, and surrounds the bones' articulating surfaces. ([https://en.wikipedia.org/w/index.php?title=Synovial_joint&oldid=1072741262 Wikipedia]) '''Lists''' * [[w:List of autoimmune diseases]] is a list of [[w:autoimmune diseases]] is categorized by [[w:organ (anatomy)|w:organ]] and tissue type to help locate diseases that may be similar. '''Organizations''' * [[w:European Alliance of Associations for Rheumatology]] is a European non-governmental organization which represents the people with arthritis/rheumatism, health professional and scientific societies of rheumatology of all the European nations. (Wikipedia) * [[w:International League of Associations of Rheumatology]] is an international body of the associations of Rheumatologists from around the world. * [[w:Arthritis Foundation]] is a nonprofit organization that is dedicated to addressing the needs of people living with arthritis in the United States. * [[w:Arthritis Australia]] - [http://arthritisaustralia.com.au/ arthritisaustralia.com.au] - Australia * [[w:Versus Arthritis]] - [https://www.versusarthritis.org/ versusarthritis.org] - UK * [http://jointhealth.org/ ''Arthritis Consumer Experts'' at jointhealth.org] - Canada * [https://spondylitis.org/ ''Spondylitis Association of America'' at spondylitis.org]- U.S.A. * [https://arthritis.ca/ The Arthritis Society at arthritis.ca] – Canada * [[w:The Swedish Rheumatism Association]] - [https://reumatiker.se/ reumatiker.se]- Sweden == Autoimmune diseases and cannabis == Cannabis helps with many [[w:autoimmune disease|autoimmune disease]]s due to its anti-inflammatory and other properties. '''Studies about autoimmune diseases and cannabis''' * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313508/ ''''''Cannabis and Autoimmunity: Possible Mechanisms of Action'''''' at ncbi.nlm.nih.gov], a Jul '''2021''' '''review''' published in [[w:ImmunoTargets & Therapy]] - '' In this review, we summarized the main mechanisms of action of medical cannabis plant especially regarding the immune system and the endocannabinoid system, looking at preliminary clinical data in three most important autoimmune diseases of three different specialities: rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease.'' * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000161/ ''''''Cannabis and Cannabinoids in the Treatment of Rheumatic Diseases'''''' at ncbi.nlm.nih.gov], a Jan '''2020''' mini-'''review''' published in the [[w:Rambam Maimonides Medical Journal]] - covers Fibromyalgia and rheumatoid arthritis, osteoarthritis and systemic sclerosis. '''Research presentations''' * [https://arthritis.ca/get-involved/participate/find-an-event-near-you/events/webinars/2021/medical-cannabis-what-research-is-revealing ''''''Medical Cannabis: What Research is Revealing'''''' 1 hr video at arthritis.ca] [https://arthritis.ca/getmedia/8d30bd2a-5be1-4a26-a08f-4fc75ac7ee8b/Slides-Medical-Cannabis-Arthritis-Talks-20210915.pdf slides] presented by Dr. Jason McDougall, Professor, Nova Scotia and moderated by Dr. Siân Bevan, Chief Science Officer of the Arthritis Society on '''2021'''-09-15. Dr. McDougall's work was kindly funded by the Arthritis Society of Canada.<ref group="1st seen in">[https://web.archive.org/web/20190612204557/http://ehealthmagz.com/2018/10/29/cannabis-could-be-reversing-damage-to-arthritic-joints/ ''''''Cannabis Could Be Reversing Damage to Arthritic Joints'''''' archived version at web.archive.org originally at ehealthmagz.com]</ref> '''Links about autoimmune diseases and cannabis''' * https://herb.co/news/health/autoimmune-diseases/ ---- == Rheumatoid arthritis and Osteoarthritis == * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453762/ ''''''Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis'''''' at ncbi.nlm.nih.gov], a 2008 study published in [[w:Arthritis Research & Therapy]] - Results: ''CB1 and CB2 protein and RNA were present in the synovia of OA and RA patients. Cannabinoid receptor stimulation of fibroblast-like cells from OA and RA patients produced a time-dependent phosphorylation of extracellular signal-regulated kinase (ERK)-1 and ERK-2 which was significantly blocked by the CB1 antagonist SR141716A. The endocannabinoids anandamide (AEA) and 2-arachidonyl glycerol (2-AG) were identified in the synovial fluid of OA and RA patients. However, neither AEA nor 2-AG was detected in synovial fluid from normal volunteers. FAAH was active in the synovia of OA and RA patients and was sensitive to inhibition by URB597 (3'-(aminocarbonyl) [1,1'-biphenyl]-3-yl)-cyclohexylcarbamate).'' ---- == Rheumatoid arthritis == ''' Links ''' * [https://www.webmd.com/rheumatoid-arthritis/features/rheumatoid-arthritis-best-worst-supplements-herbs ''''''RA: Best and Worst Supplements and Herbs'''''' at webmd.com] mentions ''[[w:Fish oil]], [[w:borage seed oil]], [[w:turmeric]], [[w:boswellia]], [[w:ginger]] and [[w:green tea extract]], [[w:probiotic]]s''. === Rheumatoid arthritis and cannabis === Cannabis helps with [[w:Rheumatoid arthritis|Rheumatoid arthritis]]. ''' Studies about rheumatic diseases and cannabis ''' * [https://www.nature.com/articles/s41419-020-02892-1 ''''''Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts'''''' at nature.com], a 2020 study published in Cell Death & Disease * [https://athmjournal.com/beyondcbd/wp-content/uploads/sites/3/2020/02/Khaleghi.pdf ''''''New Arthritis Foundation Guidelines On CBD Use Could Be First Of Many More To Come '''''' at athmjournal.com] [https://pubmed.ncbi.nlm.nih.gov/32035005/ (pubmed link)], a Feb 2020 article by Murdoc Khaleghi published in [[w:Alternative Therapies in Health and Medicine]] * [https://journals.lww.com/co-rheumatology/Abstract/2019/05000/Joints_for_joints__cannabinoids_in_the_treatment.9.aspx ''''''Joints for joints: cannabinoids in the treatment of rheumatoid arthritis'''''' at journals.lww.com], a '''2019''' '''review''' published in Current Opinion in Rheumatology ([[w:Current Opinion (Lippincott Williams & Wilkins)]]) * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685274/ 'The endocannabinoid system in pain and inflammation: Its relevance to rheumatic disease'], a 2017 article * [https://pubmed.ncbi.nlm.nih.gov/24440992/ ''''''Expression of cannabinoid receptor 2 and its inhibitory effects on synovial fibroblasts in rheumatoid arthritis '''''' at pubmed.ncbi.nlm.nih.gov], a '''2014''' '''comparative study''' published in [[w:Rheumatology (journal)]] ''' Links about Rheumatoid arthritis and cannabis ''' * [https://herb.co/news/health/greenlight-medicines-cannabis-arthritis/ ''''''Finally! A Promising UK Study On Cannabis For Arthritis'''''' at herb.co], a 2016 health reporting * [https://www.leafly.com/news/health/57-of-arthritis-patients-have-tried-cannabis-90-found-it-helped ''''''57% of Arthritis Patients Have Tried Cannabis. 90% Found It Helped'''''' at leafly.com], a June 2019 article by Alexa Peters * [https://livelovefruit.com/cannabis-for-arthritis/ ''''''Cannabis for Arthritis: How One Plant is Being Used to Repair Arthritic Joints''''' at livelovefruit.com] * [https://www.newshub.co.nz/home/lifestyle/2019/08/woman-who-uses-cannabis-to-treat-arthritis-urges-doctors-to-prescribe-to-patients-in-need.html ''''''Woman who uses cannabis to treat arthritis urges doctors to prescribe to patients in need'''''' at newshub.co.nz], a 2019 article '''Past links about rheumatoid arthritis and cannabis''' * [https://web.archive.org/web/20190612204557/http://ehealthmagz.com/2018/10/29/cannabis-could-be-reversing-damage-to-arthritic-joints/ ''''''Cannabis Could Be Reversing Damage to Arthritic Joints'''''' archived version at web.archive.org originally at ehealthmagz.com], was a Oct 2018 article === Rheumatoid arthritis and ginger === {{Q|'''[[w:Gingerol|Gingerol]]''' seems to be effective in an animal model of [[w:rheumatoid arthritis|rheumatoid arthritis]].<ref>{{cite journal |last1=Funk |first1=Janet L. |last2=Frye |first2=Jennifer B. |last3=Oyarzo |first3=Janice N. |last4=Timmermann |first4=Barbara N. |title=Comparative Effects of Two Gingerol-Containing Zingiber officinale Extracts on Experimental Rheumatoid Arthritis |journal=Journal of Natural Products |volume=72 |issue=3 |pages=403–7 |year=2009 |pmid=19216559 |pmc=2837120 |doi=10.1021/np8006183}}</ref>|Wikipedia|[[w:Gingerol|Gingerol]] and [[w:rheumatoid arthritis|rheumatoid arthritis]] as of 2019-11|Wikipedia|[[w:Gingerol|Gingerol]] and [[w:rheumatoid arthritis|rheumatoid arthritis]] as of 2019-11}} '''Studies about Rheumatoid Arthritis and ginger''' * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837120/ ''''''Comparative Effects of Two Gingerol-Containing Zingiber officinale Extracts on Experimental Rheumatoid Arthritis'''''' at ncbi.nlm.nih.gov], a 2009 study published in the [[w:Journal of Natural Products]] - Conclusion: ''Ginger is now the second member of the Zingiberaceae family demonstrated to have profound antiarthritic efficacy in the SCW-induced model of rheumatoid arthritis. The antiarthritic effects of ginger are particularly intriguing as these studies suggest that the antiarthritic bioactivity of this Zingiberaceae involves additive and/or synergistic effects of multiple components, including, but not limited to, the gingerols.'' === About Rheumatoid arthritis in Finnish / Nivelreumasta suomeksi === * [https://www.reumaliitto.fi/fi/node/598 '''''Reumataudit ja ravinto''''' at reumaliitto.fi] * [https://askelterveyteen.com/8-yrttia-niveltulehduksen-hoitoon/ ''''''8 yrttiä, joita käyttää niveltulehduksessa''''''' at askelterveyteen.com] (8 herbs to use in joint case of joint inflammation) lists ''aloe vera, uncaria tomentosa, eucalyptus, ginger, turmeric, Arnica angustifolia, willow and green tea'' ---- == Osteoarthritis == * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831737/ ''''''G Protein-Coupled Receptors in Osteoarthritis'''''' at ncbi.nlm.nih.gov], a 2021 summary article published in [[w:Frontiers in Endocrinology]] on [[w:G protein-coupled receptor]]s in Osteoarthritis Note: Cannabinoid receptors are G protein-coupled as far as I know ---- == Lupus and cannabis == Cannabis helps with [[w:Systemic lupus erythematosus|Systemic lupus erythematosus]] * https://herb.co/learn/best-cbd-strain-for-lupus/ ---- == Coeliac disease and cannabis == Cannabis helps with [[w:Coeliac disease|Coeliac disease]]. * https://herb.co/learn/celiac-disease-and-cannabis == Psoriasis and cannabis == You could also be looking for '''[[#dermatitis|dermatitis]]''', also known as eczema. Cannabis helps with [[w:Psoriasis|Psoriasis]] and when applied externally. * https://herb.co/learn/cbd-lotion-psoriasis/ * https://herb.co/guides/cbd-oil-psoriasis-eczema/ * https://hightimes.com/health/treat-psoriasis-with-cannabis/ ----
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