Revision as of 07:46, 23 February 2018

Cannabis

A lovely female Cannabis indica plants. These are often good for pain relief producing a nice body stone.

Male Cannabis sativa plants in late flowering stages.

Cannabis is the oldest and most versatile medicine known to man.

Cannabis sativa and Cannabis indica are the main cannabis variants though most strains are mixes of these. A third cannabis line is the Cannabis ruderalis, a rugged nothern cannabis that has adapted to flower even under northern long summer days.

The endocannabinoid receptors

Main article in wikipedia Endocannabinoid system

Human body contains 2 types of endocannabinoid receptors CB₁ and CB₂.

CB₁ receptors predominantly located in the nervous system, connective tissues, gonads, glands, and organs and ^[1]

CB₂ receptors, primarily found in the immune system and also present in the spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands, and reproductive organs. ^[1]

Endocannabinoids

Anandamide, an endogenous ligand of CB₁ and CB₂

Endocannabinoids are produced by our own bodies from Arachidonic acid or Omega-6 fatty acid^[2].

The two main endocannabinoids are Anandamide and 2-AG.

Anandamide

Anandamide was discovered in 1992 and it binds to both CB₁ and CB₂ receptors. The name comes from the Sanskrit word 'Ananda' meaning 'bliss' and amide from its chemistry.

It has been referred to as the endocannabinoid version of THC.

2-AG

2-Arachidonoylglycerol (2-AG) is an endogenous agonist of the CB₁ receptor

.

2-AG was discovered in 1994-1995.

Links about 2-AG

Herb.co article on 2-AG

N-Arachidonoyl dopamine

N-Arachidonoyl dopamine discovered in 2000.

2-Arachidonyl glyceryl ether

2-Arachidonyl glyceryl ether discovered in 2001.

Virodhamine

Virodhamine discovered in 2002

Lysophosphatidylinositol

Lysophosphatidylinositol is a contender to be the 6th endocannabinoid.

Phytocannabinoids

Rare 11-leafer Cannabis sativa

Many people may know the 2 most prevalent phytocannabinoids, THC and CBD.

List of known phytocannabinoids from Wikipedia:

THC (Tetrahydrocannabinol)
THCA (Tetrahydrocannbinolic acid)
CBD (Cannabidiol)
CBDA (Cannabidiolic Acid)
CBN (Cannabinol)
CBG (Cannabigerol)
CBC (Cannabichromene)
CBL (Cannabicyclol)
CBV (Cannabivarin)
THCV (Tetrahydrocannabivarin)
CBDV (Cannabidivarin)
CBCV (Cannabichromevarin)
CBGV (Cannabigerovarin)
CBGM (Cannabigerol Monomethyl Ether)
CBE (Cannabielsoin)
CBT (Cannabicitran)

THC

Tetrahydrocannabinol is a partial agonist of CB₁ located mainly in the central nervous system, and the CB₂ receptor mainly expressed in cells of the immune system.

Tetrahydrocannabinol is the psychoactive compound that brings the 'high' most recreational users are chasing.

THCA

Tetrahydrocannabinolic acid THCA is the what cannabis plants produce to fend of insects from harming it. In pure form THCA is a clear translucent crystalline of white color.

THC is produced from the raw THCA by a process called decarboxylation. Basically means to heat the stuff over certain temperature.

THCA found in raw marijuana apparently has some health enhancing properties. The issue is being researched.

http://herb.co/2017/09/13/raw-weed-benefits/

CBD

Cannabidiol has very low affinity for the cannabinoid CB₁ and CB₂ receptors receptors but acts as an indirect antagonist of cannabinoid agonists.

Cannabidiol has the most medical applications of all phytocannabinoids.

“Cannabidiol has little affinity for CB₁ and CB₂ receptors but acts as an indirect antagonist of cannabinoid agonists.^[3]”
~ Wikipedia on Cannabidiol

CBDA

Cannabidiolic Acid is the raw form. Decarboxylating CBDA yields CBD.

http://herb.co/2017/05/20/cbda/

CBN

Cannabinol

CBG

Cannabigerol

“Cannabigerol has been shown to promote apoptosis in cancer cells and inhibit tumor growth in mice. It acts as an α₂-adrenergic receptor agonist, 5-HT_1A receptor antagonist, and CB₁ receptor antagonist.^[4] It also binds to the CB₂ receptor.^[4]”
~ Wikipedia on Cannabigerol

THCV

Tetrahydrocannabivarin can be used to inhibit appetite.

Links about THCV

http://herb.co/2017/04/14/tetrahydrocannabivarin-thcv/

CBDV

Cannabidivarin

CBCV

Cannabichromevarin

CBGV

Cannabigerovarin

CBGM

Cannabigerol Monomethyl Ether

CBE

Cannabielsoin

CBT

Cannabicitran

Cannabis therapeutics

Cannabis can be applied to treat a wide assortment of illnesses. In this case it is called medical cannabis.

Due to the inbuilt default to always take the safe route and also to backup the back of your fellow MD colleague the Wikipedia does not yield the right infos on how useful and versatile a medication cannabis is.

Research has been held back by arcane laws even as cannabis is the oldest medicine known to man and it should be gladly appreciated and not outlawed because of big pharma interests.

Pain treatment with cannabis

“You just don't feel like thinking about the pain.”
~ Apotheker Jukeboksi on somatic pain relief with cannabis

“There is more to it than that.”
~ Science on above quote

Cannabis is anti-inflammatory which helps relieve some of the pain.

Epilepsy and cannabis

Full extract cannabis oil in a syringe for easy dosing and travel is usually administered in drops to the gums or under the tongue.

Cannabis can be used to treat epilepsy.

http://sorendreier.com/boy-with-100-seizures-a-day-now-has-none-after-taking-cannabis-oil/

Asthma and cannabis

http://herb.co/2017/01/11/cannabis-asthama/

Amyotrophic lateral sclerosis and cannabis

Cannabis helps with Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig's disease and motor neurone disease (MND).

http://herb.co/2017/02/01/cannabis-lou-gehrigs-disease-als/

Autoimmune diseases and cannabis

Cannabis helps with many autoimmune diseases.

Links about autoimmune diseases and cannabis

http://herb.co/2016/10/04/autoimmune-diseases/

Rheumatoid arthritis and cannabis

Cannabis helps with Rheumatoid arthritis.

Links about Rheumatoid arthritis and cannabis

http://herb.co/2016/08/06/arthritis-pain-inflammation/

Lupus and cannabis

Cannabis helps with Systemic lupus erythematosus

http://herb.co/2016/05/15/cannabis-vs-lupus/

Coeliac disease and cannabis

Cannabis helps with Coeliac disease.

http://herb.co/2016/02/12/celiac-disease-and-cannabis/

Psoriasis and cannabis

Cannabis helps with Psoriasis when applied externally.

http://herb.co/2016/05/28/skin-deep-psoriasis/

Type 1 diabetes and cannabis

http://herb.co/2015/11/17/marijuana-and-diabetes/

Multiple sclerosis and cannabis

Cannabis is very good against Multiple sclerosis.

http://herb.co/2016/07/28/marijuana-and-ms/

Cancers and cannabis

Internet is rife with stories about winning the battle against cancer with the help of phytocannabinoids. What does the science say?

Anti-proliferative - cannabis is against tumor growth ^[5]
Anti-metastatic - cannabis is against cancer spreading to other parts in the body because of metastatic activity^[5]
Anti-angiogenetic - cannabis is against new blood vein growth to tumor^[5]
Apoptotic - cannabis causes cancer cells to programmedly kill themselves via Apoptosis. ^[5]
Pain relief - cannabis works very well against the somatic and nonsomatic pains brought on by cancer.
Appetite stimulator - cannabis helps maintain a good appetite.
Anti-nauseatic - cannabis helps with the chemotherapy-induced nausea and vomiting. ^[6] if you receive chemotherapy.

Phytocannabinoids are harmless to healthy cannabinoid receptor containing cells.

Studies about cannabis and cancer

Anticancer mechanisms of cannabinoids

Testimonies about cannabis and cancer

http://drsircus.com/medical-marijuana/cannabis-cures-cancer/

Links about cannabis and cancer

http://www.calgarycmmc.com/c.htm index into studies about the health benefits of cannabis, letter 'c' lists cancers for which studies have been done.
https://www.exposingtruth.com/123-cannabis-cancer/

Videos on the Internet about phytocannabinoid treatment of cancers

Cristina Sánchez is one of the foremost researchers into the anti-cancer qualities of cannabinoids of our time.

Dr. Cristina Sanchez interview where she expains how apoptosis makes cancer cells kill themselves (a molecular biology research scientist who did her doctorates on exocannabinoids and cancers)
Dr. Cristina Sanchez on how cannabinoids work against cancers
Dr. Cristina Sanchez at Cannafest Prague 2015
Dr. Cristina Sanchez lecture in Australia (no slideshow shots, sorry)

Leukemia and cannabis

There are 2 main types of Leukemia:

Myeloid leukemia (of the bone marrow)
Lymphoid leukemia (of the lymphatic node)

Links about Lympoid and Myeloid leukemia and cannabis

Dronabinol (synthetic THC) has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns

Links about Lymphoid leukemia and cannabis

Links about Myeloid leukemia and cannabis

Prostate cancer and cannabis

Cannabis helps with prostate cancer.

herb.co/2017/01/13/prostate-cancer-cannabis/

Brain cancer and cannabis

https://herb.co/2016/07/01/cannabis-treat-brain-cancer/

Treating non-somatic issues with cannabis

Cannabis can help with various non-somatic problems such as psychiatry, depression and PTSD.

PTSD and cannabis

https://www.leafly.com/news/health/cannabis-and-post-traumatic-stress-disorder-ptsd

External links about cannabis as medicine

http://www.calgarycmmc.com/ a large compendium on medical cannabis sorted alphabetically by ailment.
http://www.encod.org/info/700-MEDICINAL-USES-OF-CANNABIS.html
http://expand-your-consciousness.com/100-scientific-studies-agree-cannabis-annihilates-cancer/ about 100 nig.gov studies linked some cases briefly described.

Literature about cannabis as a medicine

MARIJUANA AS MEDICINE? The Science Beyond the Controversy, a book published in 2000 that you can read on-line from The National Academies Press .

References

↑ ^1.0 ^1.1 https://patients4medicalmarijuana.wordpress.com/2017/07/06/how-and-why-your-brain-makes-its-own-cannabinoids/
↑ https://wakeup-world.com/2014/09/08/the-endocannabinoid-system-and-how-thc-cures-cancer/
↑ Mechoulam, Raphael; Peters, Maximilian; Murillo-Rodriguez, Eric; Hanuš, Lumír O. (2007). "Cannabidiol – Recent Advances". Chemistry & Biodiversity. 4 (8): 1678–92. doi:10.1002/cbdv.200790147. PMID 17712814.
↑ ^4.0 ^4.1 Cascio, MG; Gauson, LA; Stevenson, LA; Ross, RA; Pertwee, RG (2010). "Evidence that the plant cannabinoid cannabigerol is a highly potent α2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist". British Journal of Pharmacology. 159 (1): 129–41. doi:10.1111/j.1476-5381.2009.00515.x. PMC 2823359. PMID 20002104.
↑ ^5.0 ^5.1 ^5.2 ^5.3 http://herb.co/2016/08/25/cannabis-kills-cancer/
↑ http://herb.co/2017/01/03/cannabis-chemotherapy-induced-nausea/

[p4mm-1] 1.0 ^1.1 https://patients4medicalmarijuana.wordpress.com/2017/07/06/how-and-why-your-brain-makes-its-own-cannabinoids/

[wakeup-world-com-2] ttps://wakeup-world.com/2014/09/08/the-endocannabinoid-system-and-how-thc-cures-cancer/

[recentadvances-3] Mechoulam, Raphael; Peters, Maximilian; Murillo-Rodriguez, Eric; Hanuš, Lumír O. (2007). "Cannabidiol – Recent Advances". Chemistry & Biodiversity. 4 (8): 1678–92. doi:10.1002/cbdv.200790147. PMID 17712814.

[pmid20002104-4] 4.0 ^4.1 Cascio, MG; Gauson, LA; Stevenson, LA; Ross, RA; Pertwee, RG (2010). "Evidence that the plant cannabinoid cannabigerol is a highly potent α2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist". British Journal of Pharmacology. 159 (1): 129–41. doi:10.1111/j.1476-5381.2009.00515.x. PMC 2823359. PMID 20002104.

[herb-co-cancer-5] 5.0 ^5.1 ^5.2 ^5.3 http://herb.co/2016/08/25/cannabis-kills-cancer/

[herb-co-nausea-6] ttp://herb.co/2017/01/03/cannabis-chemotherapy-induced-nausea/

[1]

[2]

[3]

[4]

[5]

[6]

@@ Line 1: / Line 1: @@
+= Cannabis =
 [[File:Cannabis indica.jpg|thumb|right|360px|A lovely female [[w:Cannabis indica|Cannabis indica]] plants. These are often good for pain relief producing a nice body stone.]]
 [[File:Cannabis sativa 001.JPG|thumb|right|360px|Male [[w:Cannabis sativa|Cannabis sativa]] plants in late flowering stages.]]
@@ Line 7: / Line 8: @@
 [[w:Cannabis sativa|Cannabis sativa]] and [[w:Cannabis indica|Cannabis indica]] are the main cannabis variants though most strains are mixes of these. A third cannabis line is the [[w:Cannabis ruderalis|Cannabis ruderalis]], a rugged nothern cannabis that has adapted to flower even under northern long summer days.
-== Endocannabinoid receptors ==
+== The endocannabinoid receptors ==
 ''' Main article in wikipedia [[w:Endocannabinoid system|Endocannabinoid system]]'''
@@ Line 144: / Line 145: @@
 ----
-= Treating somatic issues =
+== Cannabis therapeutics ==
 Cannabis can be applied to treat a wide assortment of illnesses. In this case it is called [[w:medical cannabis|medical cannabis]].
@@ Line 152: / Line 153: @@
 Research has been held back by arcane laws even as cannabis is the oldest medicine known to man and it should be gladly appreciated and not outlawed because of big pharma interests.
-== Pain treatment ==
+== Pain treatment with cannabis ==
 {{Q|You just don't feel like thinking about the pain.|Apotheker [[User:Jukeboksi|Jukeboksi]]|somatic pain relief with cannabis}}
@@ Line 160: / Line 161: @@
 Cannabis is anti-inflammatory which helps relieve some of the pain.
-== Epilepsy ==
+== Epilepsy and cannabis ==
 [[File:FullExtractCannabisOil.jpg|thumb|right|420px|Full extract cannabis oil in a syringe for easy dosing and travel is usually administered in drops to the gums or under the tongue.]]
@@ Line 167: / Line 168: @@
 * http://sorendreier.com/boy-with-100-seizures-a-day-now-has-none-after-taking-cannabis-oil/
-== Asthma ==
+== Asthma and cannabis ==
 * http://herb.co/2017/01/11/cannabis-asthama/
-== Amyotrophic lateral sclerosis ==
+== Amyotrophic lateral sclerosis and cannabis ==
 Cannabis helps with [[w:Amyotrophic lateral sclerosis|Amyotrophic lateral sclerosis]] (ALS) also known as Lou Gehrig's disease and motor neurone disease (MND).
 * http://herb.co/2017/02/01/cannabis-lou-gehrigs-disease-als/
-== Autoimmune diseases ==
+== Autoimmune diseases and cannabis ==
 Cannabis helps with many [[w:autoimmune disease|autoimmune disease]]s.
@@ Line 182: / Line 183: @@
 * http://herb.co/2016/10/04/autoimmune-diseases/
-=== Rheumatoid arthritis ===
+=== Rheumatoid arthritis and cannabis ===
 Cannabis helps with [[w:Rheumatoid arthritis|Rheumatoid arthritis]].
@@ Line 188: / Line 189: @@
 *  http://herb.co/2016/08/06/arthritis-pain-inflammation/
-=== Lupus ===
+=== Lupus and cannabis ===
 Cannabis helps with [[w:Systemic lupus erythematosus|Systemic lupus erythematosus]]
 * http://herb.co/2016/05/15/cannabis-vs-lupus/
-=== Coeliac disease ===
+=== Coeliac disease and cannabis ===
 Cannabis helps with [[w:Coeliac disease|Coeliac disease]].
 * http://herb.co/2016/02/12/celiac-disease-and-cannabis/
-=== Psoriasis ===
+=== Psoriasis and cannabis ===
 Cannabis helps with [[w:Psoriasis|Psoriasis]] when applied externally.
 * http://herb.co/2016/05/28/skin-deep-psoriasis/
-=== Type 1 diabetes ===
+=== Type 1 diabetes and cannabis ===
 * http://herb.co/2015/11/17/marijuana-and-diabetes/
-=== Multiple sclerosis ===
+=== Multiple sclerosis and cannabis ===
 Cannabis is very good against [[w:Multiple sclerosis|Multiple sclerosis]].
@@ Line 212: / Line 213: @@
 ----
-== Cancers ==
+== Cancers and cannabis ==
 Internet is rife with stories about winning the battle against cancer with the help of phytocannabinoids. What does the science say?
@@ Line 244: / Line 245: @@
 * [https://www.youtube.com/watch?v=W53Z33Vk5T8 Dr. Cristina Sanchez lecture in Australia] (no slideshow shots, sorry)
-=== Leukemia ===
+=== Leukemia and cannabis ===
 There are 2 main types of Leukemia:
 * [[w:Myeloid leukemia|Myeloid leukemia]] (of the bone marrow)
@@ Line 261: / Line 262: @@
 * http://www.healthmj.com/cancer/donavon-vizina-on-treating-acute-myeloid-leukemia-with-cannabis-oil/
-=== Prostate cancer ===
+=== Prostate cancer and cannabis ===
 Cannabis helps with [[w:prostate cancer|prostate cancer]].
 * herb.co/2017/01/13/prostate-cancer-cannabis/
-=== Brain cancer ===
+=== Brain cancer and cannabis ===
 * https://herb.co/2016/07/01/cannabis-treat-brain-cancer/
 ----
-= Treating non-somatic issues =
+== Treating non-somatic issues with cannabis ==
 Cannabis can help with various non-somatic problems such as psychiatry, depression and [[w:PTSD|PTSD]].
-== PTSD ==
+== PTSD and cannabis ==
 * https://www.leafly.com/news/health/cannabis-and-post-traumatic-stress-disorder-ptsd
-== External links ==
+== External links about cannabis as medicine ==
 * http://www.calgarycmmc.com/ a large compendium on medical cannabis sorted alphabetically by ailment.
 * http://www.encod.org/info/700-MEDICINAL-USES-OF-CANNABIS.html
 * http://expand-your-consciousness.com/100-scientific-studies-agree-cannabis-annihilates-cancer/ about 100 nig.gov studies linked some cases briefly described.
-== Literature ==
+== Literature about cannabis as a medicine ==
 * [https://www.nap.edu/read/9586/chapter/1 MARIJUANA AS MEDICINE? The Science Beyond the Controversy], a book published in 2000 that you can read on-line from The National Academies Press .
-== References ==
+= References =
 <references/>